Kinetin (or Vivakin) was introduced as Kinerase in the US as a new
ingredient for the treatment of age related photodamage of skin. This 6-
furfurylaminopurine is a synthetic cytokinin, a family of plant growth factors, and
was shown to be a highly potent growth factor. In vitro, it was able to delay or
prevent the onset of age-related changes in skin cells without affecting cellular
lifespan. In a double-blind clinical trial, Kinetin (0.005%) partially reversed the
clinical signs of photodamaged skin and demonstrated a good safety profile.
It could have potential in psoriasis as well as in other proliferative skin disorders.
Kinetin is a cytokinin plant growth regulator with diverse biological activities. Kinetin (0.23 μM) increases p34cdc2-like histone H1 kinase activity, the number of cells in mitosis, and total cell number in arrested N. plumbaginifolia cells. It increases GSH levels and activity of glutathione peroxidase and glutathione reductase, but reduces thiobarbituric acid reactive substances (TBARS) levels, in human skin fibroblasts when used at a concentration of 10 μM. Kinetin (40 μM) reduces age-related enlargement, multinucleation, and accumulation of cellular debris in human mammary skin fibroblasts without affecting proliferative lifespan.
A cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures
Kinetin acts as plant growth accelerator, auxin, plant growth regulator, plant cell division promotor. It also acts as cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures.
Plant growth regulator. To augment growth of microbial cultures: BE 632589 (1963 to Hoechst).
ChEBI: Kinetin is a member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group. It has a role as a geroprotector and a cytokinin. It is a member of furans and a member of 6-aminopurines.
Kinetin is an artificialcytokinin, obtained from herring sperm. It is named due to its ability to stimulate cell division.
FAPα has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen. It has also been reported that FAPa has a tumor suppressor activity.
To obtain some new analogs of kinetin we used as the starting materials 3-aryl-1-bromobutanes, which are readily available at the present time. The synthesis was carried out by the following route:
It forms platelets from EtOH and sublimes at 220o, but is best done at lower temperatures in a good vacuum. It has been extracted from neutral aqueous solutions with Et2O. [Miller et al J Am Chem Soc 78 1375 1956, Bullock et al. J Am Chem Soc 78 3693 1956, Beilstein 26 III/IV 3586.]
[1] TORREY J G. Kinetin as trigger for mitosis in mature endomitotic plant cells[J]. Experimental cell research, 1961, 23 2: Pages 281-299. DOI:
10.1016/0014-4827(61)90038-6[2] ABDULSALAM REDHWAN F Arda Acemi. Effects of plant growth regulators on in vitro seed germination, organ development and callogenesis in Pancratium maritimum L.[J]. Plant Cell, Tissue and Organ Culture (PCTOC), 2023, 184 2 1: 97-110. DOI:
10.1007/s11240-023-02514-6[3] A. JABOSKA-TRYPU R C M Matejczyk. N6-benzyladenine and kinetin influence antioxidative stress parameters in human skin fibroblasts[J]. Molecular and Cellular Biochemistry, 2016, 413 1: 97-107. DOI:
10.1007/s11010-015-2642-5[4] THIAGO MORENO L SOUZA. Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation.[J]. Nature Communications, 2023, 14 1: 199. DOI:
10.1038/s41467-023-35928-z
