S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE

BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with K_i values of 0.4 and 0.6 μM from kinetic analyses. It is also a potent inhibitor of human arginase II with K_i values of 310 and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.

BEC Hydrochloride is Arginase II inhibitor. For the biological study of the inhibition of arginase II, it prevented nitrate tolerance in human umbilical vein endothelial cell and in mouse aorta.