MT-7716 is a Novel selective nonpeptidergic NOP receptor agonist, effectively blocking ethanol-induced increase in GABAergic transmission, decreasing spontaneous miniature inhibitory postsynaptic currents (mIPSCs) in central amygdala (CeA).
Uses
MT-7716 hydrochloride (W-212393 hydrochloride) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention[1].
IC 50
NOP Receptor/ORL1
References
[1] de Guglielmo G, et al, MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats. Addict Biol. 2015 Jul;20(4):643-51. DOI:10.1111/adb.12157
