LY-310762 Hydrochloride is a selective and potent SR-1D and 5-hydroxytryptamine (5-HT1D) receptor-preferring antagonist.
ChEBI: LY-310762 hydrochloride is a hydrochloride resulting from the formal reation of equimolar amount of LY-310762 with hydrogen chloride. A potent and selective antagonist for the 5-hydroxytryptamine 1D (5-HT1D) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It contains a LY-310762(1+).
5-HT 1D -preferring receptor antagonist (EC 50 = 31 nM). Displays no activity on 5-HT transport.
LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo[1].
LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model[2].
| Animal Model: | Dunkin Hartley guinea pigs (female; 350-400 g, Harlan)[1]. |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; single |
| Result: | Produced a further significant enhancement in the 5-HT response to fluoxetine. |
| Animal Model: | Male Wistar rats (270-330 g; phenylephrine-infusion rats model)[2]. |
| Dosage: | 1 mg/kg |
| Administration: | Intravenous injection; single |
| Result: | Completely abolished 5-HT vasodilator effects. |
5-HT1D Receptor: 249 nM (Ki)
room temperature (desiccate)
