CDK5 INHIBITOR 20-223
英文名称:CDK5 inhibitor 20-223
(CP 668863)
CAS号:865317-30-2
分子式:C19H19N3O
分子量:305.37
EINECS号:
Mol文件:865317-30-2.mol
CDK5 INHIBITOR 20-223 用途与合成方法
CDK5 inhibitor 20-223 是一种有效的 CDK2 和 CDK5 抑制剂，IC50 分别为 6.0 和 8.8 nM。CDK5 inhibitor 20-223 有潜力用于结肠直肠癌 (CRC) 的研究。
|
CDK2 6.0 nM (IC 50 ) |
CDK5 8.8 nM (IC 50 ) |
CDK5 inhibitor 20-223 (10 nM-10 μM; 72 hours) potently inhibits cell growth in a panel of colorectal cancer (CRC) cell lines.
CDK5 inhibitor 20-223 (0.3125-20 μM; 6 hours) induces a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels in each of the three CRC cell lines.
Cell Viability Assay
| Cell Line: | CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells |
| Concentration: | 10 μM, 1 μM, 100 nM, 10 nM |
| Incubation Time: | 72 hours |
| Result: | Reduced cell growth. IC50s of 168±20, 480±41, 360±72, 763±92, 117±49, 568±49, 79±31 nM for SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells. |
Western Blot Analysis
| Cell Line: | CRC cell lines GEO, HCT116 and HT29 |
| Concentration: | 20, 10, 5, 2.5, 1.25, 0.625, 0.3125 μM |
| Incubation Time: | 6 hours |
| Result: |
Did not affect the total levels of CDK2/5, and the levels of total FAK or total Retinoblastoma protein (Rb).
Induced a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels. |
CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice.
| Animal Model: | Athymic nude mice |
| Dosage: | 8 mg/kg |
| Administration: | Injections were given subcutaneously daily for the first week and every other day for two more weeks for a total of 14 injections. |
| Result: | Reduced tumor growth and tumor weight in vivo. |
CDK5 INHIBITOR 20-223 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-123772 | 1 mg | 909 | ||
| 2024-04-30 | HY-123772 | CDK5 INHIBITOR 20-223 | 865317-30-2 | 5mg | 2000 |
CDK5 INHIBITOR 20-223供应商 更多
北京普西唐生物科技有限公司
联系电话：010-60605840 18892239720
产品介绍：
英文名称：CDK5 inhibitor 20-223
CAS：865317-30-2
纯度：98%
包装信息：5mg;10mg
ChemeGen 中国
联系电话： 18818260767
产品介绍：
英文名称：CDK5 inhibitor 20-223
CAS：865317-30-2
纯度：98%
包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注：品牌：ChemeGen
天津普西唐生物医药科技有限公司
联系电话：010-60605840
产品介绍：
英文名称：CDK5 inhibitor 20-223
CAS：865317-30-2
纯度：98%
包装信息：5mg;10mg
TargetMol中国（陶术生物）
联系电话： 4008200310
产品介绍：
英文名称：CDK5 inhibitor 20-223;CDK5 inhibitor 20223,CDK5 inhibitor 20 223,CDK-5 inhibitor 20-223
CAS：865317-30-2
纯度：98%
包装信息：50 mg
上海陌孚医药科技有限公司
联系电话：021-59167510 18117107507
产品介绍：
英文名称：CDK5 inhibitor 20-223
CAS：865317-30-2
纯度：>=99%
包装信息：100mg;5mg;50mg;10mg;200mg;10mM*1mLinDMSO;25mg
