White to pale brown solid
3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors.
3-Picolyl chloride hydrochloride is an organic synthetic reagent for the preparation of N,N-bis(pyridin-2-ylmethyl)aniline ligands, 2-oxodihydroquinoline-3-carboxamide derivatives, and 3β-amino-tropane arylamide derivatives with atypical antipsychotic profiles. It is also used in the preparation of novel bifunctional anion exchange resins for nuclear waste treatment.
Yellow powder or yellow-tan solid with an irritating odor.
Hygroscopic. Water soluble.
3-Picolyl chloride hydrochloride is incompatible with strong oxidizing agents and strong bases.
Flash point data for 3-Picolyl chloride hydrochloride are not available; however, 3-Picolyl chloride hydrochloride is probably combustible.
Suspected carcinogen
with experimental carcinogenic data. Poison
by ingestion. Mutation data reported. When
heated to decomposition it emits very toxic
fumes of NOx and Cl-.
