TPCK CAS#: 402-71-1

TPCK

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TPCK Basic information

TPCK Chemical Properties

Melting point:106-108 °C(lit.)
Boiling point:509.9±60.0 °C(Predicted)
Density 1.1350 (rough estimate)
refractive index 1.6100 (estimate)
storage temp. −20°C
solubility DMSO: >10 mg/mL stable for several months at 4°C.
pka8.71±0.50(Predicted)
form powder
color white
BRN 2895215
CAS DataBase Reference402-71-1
EPA Substance Registry SystemBenzenesulfonamide, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl- (402-71-1)

Safety Information

MSDS

TPCK Usage And Synthesis

Chemical Propertieswhite crystalline powder
UsesN-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. I t promotes dephosphorylation of p53 on serine residues.
DefinitionChEBI: The N-tosyl derivative of L-phenylalanyl chloromethyl ketone.
Safety ProfileExperimental reproductive effects. A flammable liquid. When heated to decomposition it emits toxic fumes of NOx, SOx, and Cl-.

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