(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID 性质
| 沸点 | 523.1±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.506±0.06 g/cm3(Predicted) |
| 储存条件 | Desiccate at +4°C |
| 溶解度 | 在水中的溶解度为≥2mg/mL（加热） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 1.83±0.10(Predicted) |
| 颜色 | 白色至米色 |
(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID 用途与合成方法
In the hippocampal slice in vitro, CGP 37849 selectively and reversibly antagonizes NMDA-evoked increases in CA1 pyramidal cell firing rate. In slices bathed in medium containing low Mg 2+ levels, concentrations of CGP 37849 up to 10 μM suppresses burst firing evoked in CA1 neurones by stimulation of Schaffer collateral-commissural fibres without affecting the magnitude of the initial population spike.
CGP 37849 potently (
K
i
of 220 nM) and competitively inhibits NMDA-sensitive l-[
3
H]-glutamate binding to postsynaptic density (PSD) fractins from rat brain. CGP 37849 inhibits the binding of the selective NMDA receptor antagonist, [
3
H]-(±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP), with a
K
i
of 35 nM.
In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurones induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate.
Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an
ED
50
of 21 mg/kg.
(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-107702 | (E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID | 127910-31-0 | 1mg | 1550 |
| 2024-11-08 | HY-107702 | (E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID | 10 mM * 1 mLin DMSO | 3566 |
