Hecogenin, is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties.
ChEBI: Hecogenin is a triterpenoid.
Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1].
| Animal Model: | Male Swiss mice (20-30 g) with ethanol[1] |
| Dosage: | 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg |
| Administration: | Oral administration; for 15 hours |
| Result: | Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.
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The saponin (~35 mg) in EtOAc is chromatographed on Al2O3 and eluted with *C6H6/Et2O, and the residue on evaporation is recrystallised from Me2CO. [Mazur et al. J Am Chem Soc 82 5889 1960, Marker et al. J Am Chem Soc 69 2167 1947, Beilstein 19 III/IV 2581.]
