氟辛克生
氟辛克生 性质
| 比旋光度 | D +26° (c = 1 in methanol) |
|---|---|
| 沸点 | 635.8±55.0 °C(Predicted) |
| 密度 | 1.271±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：31.25 mg/mL（75.22 mM） |
| 酸度系数(pKa) | 14.09±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
氟辛克生 用途与合成方法
|
5-HT 1A Receptor 24 nM (EC 50 ) |
Flesinoxan acts as a partial agonist at postsynaptic and as a full agonist at presynaptic 5-HT1A receptors. The capacity of Flesinoxan to antagonize the effect of 5-HT on CA3 pyramidal neurons was similar to that of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT).
The intravenous administration of Flesinoxan suppresses the firing activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons. The acute brain penetration of [
3
H]Flesinoxan and [
3
H]8-OH-DPAT are determined. Nine minutes after intravenous administration, [
3
H]8-OH-DPAT reached significantly greater brain concentration than [
3
H]Flesinoxan.
Subcutaneous administration of Flesinoxan and 8-OH-DPAT produce a dose-dependent hypothermia. The Flesinoxan-induced hypothermia is significantly attenuated by prior administration of the non-selective 5-HT1A antagonist pindolol and the 5-HT1/2 antagonist methysergide. Similar degrees of hypothermia are achieved with 3 mg/kg of Flesinoxan and 0.5 mg/kg of 8-OH-DPAT. The maximal effect of Flesinoxan occurs 30 min later than that of 8-OH-DPAT and fades more slowly.
氟辛克生 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-121653 | 1 mg | 2045 | ||
| 2024-11-08 | HY-121653 | 氟辛克生 | 98206-10-1 | 5mg | 4500 |
