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2-Oxetanone Basic information
2-Oxetanone Chemical Properties
  • Melting point:−33 °C(lit.)
  • Boiling point:162 °C(lit.)
  • Density 1.146 g/mL at 25 °C(lit.)
  • vapor pressure 3 at 25 °C (NIOSH, 1997)
  • refractive index n20/D 1.412(lit.)
  • Flash point:158 °F
  • storage temp. 2-8°C
  • solubility Miscible with acetone, alcohol, chloroform, and ether (Windholz et al., 1983)
  • form Liquid
  • color Colorless liquid with a sweet but irritating odor
  • Water Solubility 37 g/100 mL
  • Sensitive Moisture Sensitive
  • Merck 14,7820
  • Henry's Law Constant7.6 at 25 °C (approximate - calculated from water solubility and vapor pressure)
  • CAS DataBase Reference57-57-8(CAS DataBase Reference)
  • IARC2B (Vol. 4, Sup 7, 71) 1999
  • NIST Chemistry Reference«beta»-Propiolactone(57-57-8)
  • EPA Substance Registry Systembeta-Propiolactone (57-57-8)
Safety Information
  • Hazard Codes T+
  • Risk Statements 45-26-36/38
  • Safety Statements 53-45-99
  • RIDADR UN 3382 6.1/PG 1
  • WGK Germany 3
  • RTECS RQ7350000
  • TSCA Yes
  • HazardClass 6.1
  • PackingGroup I
  • HS Code 29322090
  • Hazardous Substances Data57-57-8(Hazardous Substances Data)
  • ToxicityLC50 (inhalation) for rats 25 ppm/6-h (quoted, RTECS, 1985).
2-Oxetanone Usage And Synthesis
  • Chemical PropertiesColorless to light yellow liqui
  • Chemical Propertiesβ-Propiolactone is a colorless liquid which slowly hydrolyzes to hydracrylic acid and must be cooled to remain stable.
  • UsesReacts with bacteriphage DNA causing inactivation, repair and recombination
  • Usesantiandrogen
  • UsesVersatile intermediate in organic synthesis.
  • brand nameBetaprone (Forest).
  • General DescriptionA colorless liquid with a slightly sweetish, pungent odor. Used as an intermediate in organic synthesis; disinfectant, sterilant for blood plasma, tissue grafts, vaccines, enzymes and surgical instruments.
  • Air & Water ReactionsSlow reaction with water to form beta- hydroxypropionic acid.
  • Reactivity Profile2-Oxetanone is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. 2-Oxetanone may be incompatible with alkalis.
  • HazardStrong skin and upper respiratory tract irri- tant, skin cancer. Possible carcinogen. Worker expo- sure should be minimized.
  • Health HazardThe toxicity potential of 2-Oxetanone via inhalation or ingestion is high; may cause death or permanent injury after very short exposures to small quantities. It is a carcinogen.
  • Fire HazardContainers may explode. When heated to decomposition, 2-Oxetanone emits acrid smoke and fumes. Stable when stored at 41F. Avoid storing in areas of exposure to the direct rays of the sun and in areas of high fire hazard. Tends to polymerize on storage. Avoid elevated temperatures.
  • Safety ProfileConfirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by inhalation. Moderately toxic by intraperitoneal route. An initiator. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Potential Exposureβ-Propiolactone is used as a chemical intermediate in synthesis of acrylic acid and esters, acrylate plastics; as a vapor sterilizing agent; phase disinfectant; and a viricidal agent.
  • Carcinogenicityβ-Propiolactone is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
  • Environmental FateChemical/Physical. Slowly hydrolyzes to hydracrylic acid (Windholz et al., 1983). In a reactor heated to 250 °C and a pressure of 12 mmHg, β-propiolactone decomposed to give equal amounts of ethylene and carbon dioxide (James and Wellington, 1969).
  • ShippingUN3382 Toxic by inhalation liquid, n.o.s. with an LC 50 ≤1000 mL/m 3 and saturated vapor concentration ≥10 LC 50 , Hazard class: 6.1; Labels: 6.1 Technical Name Required, Inhalation Hazard Zone B. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
  • Purification MethodsFractionally distil the lactone from sodium under reduced pressure. It gives an acidic solution in H2O. It irritates the skin and is a possib
  • IncompatibilitiesReacts with water, causing decomposi- tion and forming 3-hydroxypropionic acid (CAS: 503-66- 3), an irritant. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Incompatible with acet- ates, halogens, thiocyanates, thiosulfates, strong oxidizers; strong bases. Forms explosive mixture with air above 75℃. May polymerize upon storage or due to warming. Stable if kept under refrigeration @ 5 to 10 ℃/40 to 50 ℃.
  • Waste DisposalDissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
2-Oxetanone Preparation Products And Raw materials
2-Oxetanone(57-57-8)Related Product Information
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