Trimeprazine
- Product Name:Trimeprazine
- CAS:84-96-8
- MF:C18H22N2S
- MW:298.45
- EINECS:201-577-3
- Mol File:84-96-8.mol
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Trimeprazine Chemical Properties
- Melting point:68°C
- Boiling point:bp0.3 150-175°
- Density 1.1163 (rough estimate)
- refractive index 1.6000 (estimate)
- pkapKa 9.00 (Uncertain)
- Water Solubility 0.942 mg/L
- CAS DataBase Reference84-96-8
- NIST Chemistry ReferenceTrimeprazine(84-96-8)
- Hazardous Substances Data84-96-8(Hazardous Substances Data)
- Language:EnglishProvider:Alimemazine
Trimeprazine Usage And Synthesis
- OriginatorTemaril,SKF,US,1958
- Usesantipruritic
- Manufacturing Process95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6
grams) in xylene (140 cc) at a temperature of 130°C and the mixture is
heated with reflux for 2 hours.
A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in xylene is then added over 50 minutes and heating with reflux is continued for 20 hours. After cooling, the mixture is treated with water (40 cc) and N methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with ether.
The extract is dried over potassium carbonate and evaporated and the residue is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (12.6 grams) is collected, distilling between 150° and 175°C under a pressure of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C. - brand nameTemaril (Allergan).
- Therapeutic FunctionAntipruritic
- cyamemazine perimetazine Levomepromazine hydrochloride Trimeprazine tartrate MEQUITAZINE, [2-14C]- METHDILAZINE HYDROCHLORIDE (200 MG) METHDILAZINE (200 MG) Etymemazine (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT MEQUITAZINE pecazine Trifluomeprazine OXOMEMAZINE methiomeprazine Trimeprazine Bis(2-ethylhexyl)amine Diethanolamine (-)-2-[METHYLAMINO]-1-PHENYLPROPANE
TrimeprazineSupplierMore
- Company Name:Shanghai TaoSu Biochemical Technology Co., Ltd.
- Tel:021-33632979
- Email:info@tsbiochem.com
- Company Name:Shanghai BeiZhuo Biotech Co., Ltd.
- Tel:021-61119791/13386096464
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- Company Name:Shanghai Meishui Chemical Technology Co., Ltd
- Tel:021-60549325 18616193163
- Email:mail@meishuichem.com
- Company Name:ChemStrong Scientific Co.,Ltd
- Tel:15920483169 0755-66853366-
- Email:sales@chem-strong.com
- Company Name:Hangzhou J&H Chemical Co., Ltd.
- Tel:0571-87396432-
- Email:sales@jhechem.com;