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Trimeprazine

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Trimeprazine Basic information
Trimeprazine Chemical Properties
  • Melting point:68°C
  • Boiling point:bp0.3 150-175°
  • Density 1.1163 (rough estimate)
  • refractive index 1.6000 (estimate)
  • pkapKa 9.00 (Uncertain)
  • Water Solubility 0.942 mg/L
  • CAS DataBase Reference84-96-8
  • NIST Chemistry ReferenceTrimeprazine(84-96-8)
Safety Information
MSDS
Trimeprazine Usage And Synthesis
  • OriginatorTemaril,SKF,US,1958
  • Usesantipruritic
  • Manufacturing Process95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6 grams) in xylene (140 cc) at a temperature of 130°C and the mixture is heated with reflux for 2 hours.
    A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in xylene is then added over 50 minutes and heating with reflux is continued for 20 hours. After cooling, the mixture is treated with water (40 cc) and N methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with ether.
    The extract is dried over potassium carbonate and evaporated and the residue is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (12.6 grams) is collected, distilling between 150° and 175°C under a pressure of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C.
  • brand nameTemaril (Allergan).
  • Therapeutic FunctionAntipruritic
Trimeprazine(84-96-8)Related Product Information
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