Trimeprazine CAS#: 84-96-8

ChemicalBook > Product Catalog > API > Antiallergic drugs > Antihistamines > Trimeprazine

Trimeprazine

Basic information Safety Related Supplier

Trimeprazine Basic information

Trimeprazine Chemical Properties

Safety Information

MSDS

Trimeprazine Usage And Synthesis

OriginatorTemaril,SKF,US,1958
Usesantipruritic
UsesTrimeprazine is used for treating itching during dermatitis of both allergic and nonallergic origin.
Manufacturing Process95% sodamide (2.77 grams) is added to a solution of phenthiazine (9.6 grams) in xylene (140 cc) at a temperature of 130°C and the mixture is heated with reflux for 2 hours.
A 0.61 N solution (90 cc) of 1-chloro-2-methyl-3-dimethylaminopropane in xylene is then added over 50 minutes and heating with reflux is continued for 20 hours. After cooling, the mixture is treated with water (40 cc) and N methanesulfonic acid (70 cc). The aqueous layer is washed with ether, treated with aqueous sodium hydroxide (density = 1.33; 10 cc) and extracted with ether.
The extract is dried over potassium carbonate and evaporated and the residue is distilled in vacuo. 3-(10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (12.6 grams) is collected, distilling between 150° and 175°C under a pressure of about 0.3 mm Hg. By dissolving this base in acetone and adding ethereal hydrogen chloride, a hydrochloride is obtained, MP 216° to 217°C.
brand nameTemaril (Allergan).
Therapeutic FunctionAntipruritic

Trimeprazine(84-96-8)Related Product Information

TrimeprazineSupplierMore