Ibudilast CAS#: 50847-11-5

ChemicalBook > Product Catalog > API > Antiallergic drugs > Allergic Reactions > Ibudilast

Ibudilast

Basic information Safety Related Supplier

Ibudilast Basic information

Ibudilast Chemical Properties

Safety Information

MSDS

Ibudilast Usage And Synthesis

DescriptionIbudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.
Chemical PropertiesWhite Solid
OriginatorKyorin (Japan)
Usesa phosphodiesterase inhibitor with anti-inflammatory activity
UsesInhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]
UsesA leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)
brand nameKetas
Biological ActivityPhosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

Ibudilast Preparation Products And Raw materials

Ibudilast(50847-11-5)Related Product Information

IbudilastSupplierMore