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Ibudilast

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Ibudilast Basic information
Ibudilast Chemical Properties
  • Melting point:53-54°C
  • Boiling point:175°C/7.5mmHg(lit.)
  • Density 1.09
  • refractive index 1.5500 (estimate)
  • storage temp. 2-8°C
  • solubility DMSO: 28 mg/mL, soluble
  • form solid
  • color white
  • Merck 14,4879
  • InChIKeyZJVFLBOZORBYFE-UHFFFAOYSA-N
  • CAS DataBase Reference50847-11-5(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22-36/37/38
  • Safety Statements 26-36
  • WGK Germany 3
  • RTECS UR0711200
  • ToxicityLD50 i.v. in mice: 260 mg/kg (Irikura, 1973)
MSDS
Ibudilast Usage And Synthesis
  • DescriptionIbudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.
  • Chemical PropertiesWhite Solid
  • OriginatorKyorin (Japan)
  • Usesa phosphodiesterase inhibitor with anti-inflammatory activity
  • UsesInhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]
  • UsesA leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)
  • brand nameKetas
  • Biological ActivityPhosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.
Ibudilast Preparation Products And Raw materials
Ibudilast(50847-11-5)Related Product Information
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  • Company Name:Shandong Chenxi Pharmaceutical Co., Ltd. Gold
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