Ibudilast
- Product Name:Ibudilast
- Synonyms: 2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE 3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE Ibudilast 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one Ibudilast, >=98% budilast 1-propanone 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine KC-404
- CAS:50847-11-5
- MF:C14H18N2O
- MW:230.31
- EINECS:637-150-7
- Product Categories: Inhibitors Intermediates & Fine Chemicals - Pharmaceuticals Cyclic Nucleotide related Amines Heterocycles API
- Mol File:50847-11-5.mol
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Ibudilast Chemical Properties
- Melting point:53-54°C
- Boiling point:175°C/7.5mmHg(lit.)
- Density 1.09
- refractive index 1.5500 (estimate)
- storage temp. 2-8°C
- solubility DMSO: 28 mg/mL, soluble
- form solid
- color white
- Merck 14,4879
- InChIKeyZJVFLBOZORBYFE-UHFFFAOYSA-N
- CAS DataBase Reference50847-11-5(CAS DataBase Reference)
- Hazard Codes Xn
- Risk Statements 22-36/37/38
- Safety Statements 26-36
- WGK Germany 3
- RTECS UR0711200
- ToxicityLD50 i.v. in mice: 260 mg/kg (Irikura, 1973)
- Language:EnglishProvider:2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
- Language:EnglishProvider:SigmaAldrich
Ibudilast Usage And Synthesis
- DescriptionIbudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.
- Chemical PropertiesWhite Solid
- OriginatorKyorin (Japan)
- Usesa phosphodiesterase inhibitor with anti-inflammatory activity
- UsesInhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]
- UsesA leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)
- brand nameKetas
- Biological ActivityPhosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.
Ibudilast Preparation Products And Raw materials
- Raw materialsSodium acetate2-PicolineIsobutyric anhydride
- Ibudilast Bensulfuron methyl Citric acid monohydrate Parathion-methyl Kresoxim-methyl Thiophanate-methyl ULINASTATIN Cefazolin 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Methylparaben Cilastatin Imipenem-Cilastatin sodium hydrate Methyl Methyl bromide Methyl acrylate Isobutyryl chloride Naphazoline hydrochloride METHYL THIOPHENE-2-CARBOXYLATE
IbudilastSupplierMore
- Company Name:Shandong Chenxi Pharmaceutical Co., Ltd. Gold
- Tel:0531-88803416 13153166250
- Email:sales@chemedpharma.com
- Company Name:JinanGongchuang Pharmaceutical Technology Co. Ltd.. Gold
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- Company Name:Suizhou Jiake Biological Engineering Co., Ltd. Gold
- Tel:0722-3632989；18008664499;0722-3632789；18008664168
- Email:2286801987@qq.com
- Company Name:Beijing Huikang Boyuan Chemical Tech Co., Ltd
- Tel:010-68862197
- Email:bjhkby@126.com
- Company Name:Shanghai Boyle Chemical Co., Ltd.
- Tel:
- Email:sales@boylechem.com