7,8,9,10-TETRAHYDRO-BENZO[A]PYREN-7-OL

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.

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7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.[Cayman Chemical]

7,8,9,10-Tetrahydro-benzo[a]pyren-7-ol is a Benzopyrene (B205800) derivative, activated by hepatic cytosol.

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol (7-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene), a polycyclic aromatic hydrocarbon (PAH), is a substituted benzopyrene. Its bromination reaction with N-bromosaccharin (NBSac) has been investigated. The sulfotransferase-assisted activation of 7-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene to form electrophilic, mutagenic, or tumorigenic sulfuric acid ester metabolite, which binds covalently to DNA and leads to mutation, has been reported.

[1] H GLATT. Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat.[J]. Carcinogenesis, 1994, 15 11: 2605-2611. DOI: 10.1093/carcin/15.11.2605
[2] YOUNG-JOON SURH  Steven R T. Sulfotransferase-Mediated Activation of 7,8,9,10-Tetrahydro-7-ol, 7,8-Dihydrodiol, and 7,8,9,10-Tetraol Derivatives of Benzo[a]pyrene[J]. Chemical Research in Toxicology, 1995, 8 5: 693-698. DOI: 10.1021/tx00047a008