基本属性 生物活性靶点体外研究体内研究 用途与合成方法 甲醇中妥布特罗溶液标准物质 价格(试剂级) 新闻专题 相关产品
网站主页  化工产品目录 原料药  呼吸系统用药  平喘药  甲醇中妥布特罗溶液标准物质

甲醇中妥布特罗溶液标准物质

甲醇中妥布特罗溶液标准物质

英文名称:Tulobuterol hydrochloride
CAS号:56776-01-3
分子式:C12H19Cl2NO
分子量:264.19
EINECS号:634-677-4
Mol文件:56776-01-3.mol
甲醇中妥布特罗溶液标准物质 结构式

甲醇中妥布特罗溶液标准物质 性质

熔点 159-163℃
储存条件 2-8°C
溶解度 可溶于DMSO(少许)、甲醇(少许)
颜色 白色
水溶解性 Soluble in methanol or water.
敏感性 Hygroscopic
Merck 14,9811
InChIKey RSLNRVYIRDVHLY-UHFFFAOYSA-N
CAS 数据库 56776-01-3(CAS DataBase Reference)

甲醇中妥布特罗溶液标准物质 用途与合成方法

Tulobuterol是长效的β2-adrenergic receptor激动剂,具有支气管扩张、消炎和抗病毒活性。

β2-adrenoceptor

Tulobuterol (0.1 μM; 24 hours or 72 hours; human tracheal epithelial cells) treatment decreases the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells treated with tulobutero are significantly lower than those in the cells treated with vehicle before RV14 infection. Treatment with tulobuterol reduces the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduces the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. Tulobuterol treatment produces a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.

RT-PCR

Cell Line: Human tracheal epithelial cells infected with RV14
Concentration: 0.1 μM
Incubation Time: 24 hours or 72 hours
Result: Decreased the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells were significantly lower. Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduced the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. And produced a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.

In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h.

类别
有毒物质
毒性分级
高毒
急性毒性
口服-大鼠 LD50: 560 毫克/公斤; 口服-小鼠 LD50: 243 毫克/公斤
可燃性危险特性
热分解排出有毒氮氧化物, 氯化物气体
储运特性
库房通风低温干燥; 与食品原料类分开存放
灭火剂
水,干粉、干砂、二氧化碳、泡沫、1211灭火剂

安全信息

危险品标志Xn
危险类别码22
WGK Germany3
RTECS号DN8785000
海关编码2922.19.7000

甲醇中妥布特罗溶液标准物质 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-04-30 HY-W011733 250 mg 650
2024-04-30 HY-W011733 盐酸妥布特罗 56776-01-3 10mM * 1mLin DMSO 715

甲醇中妥布特罗溶液标准物质新闻专题 更多

"甲醇中妥布特罗溶液标准物质"相关产品信息