宝藿苷Ⅰ
宝藿苷Ⅰ 性质
| 熔点 | 202-203 °C |
|---|---|
| 沸点 | 759.4±60.0 °C(Predicted) |
| 密度 | 1.46 |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 可溶于二甲基亚砜、甲醇 |
| 酸度系数(pKa) | 6.29±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄色 |
宝藿苷Ⅰ 用途与合成方法
|
CXCR4
|
Baohuoside I is an inhibitor of CXCR4, and downregulates CXCR4 expression at 12-25 μM. Baohuoside I (0-25 μM) suppresses NF-κB activation in a dose-dependent manner, suppresses CXCL12 induced the invasion of cervical cancer cells. Baohuoside I also inhibits invasion of breast cancer cells. Baohuoside I inhibits A549 cell viability, with IC 50 s of 25.1 μM at 24 h, 11.5 μM and 9.6 μM at 48 h and 72 h, respectively. Baohuoside I ((25 μM) suppresses the caspase cascade in A549 cells, elevates ROS levels and activates JNK and p38 MAPK signaling cascade. Baohuoside I (3.125, 6.25, 12.5, 25.0 and 50.0 µg/mL) significantly and dose-dependently blocks the growth of esophageal squamous cell carcinoma Eca109 cells, with an IC 50 of 4.8 µg/mL at 48 h.
Baohuoside I (25 mg/kg) decreases β-catenin protein levels, cyclin D1 and survivin expression in nude mice.
宝藿苷Ⅰ 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-N0011 | 宝藿苷I | 113558-15-9 | 5 mg | 800 |
| 2024-11-08 | HY-N0011 | 宝藿苷I | 113558-15-9 | 10mg | 1200 |
