唑来磷酸
唑来磷酸 性质
| 熔点 | 245 °C(dec.) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | H2O：≥2mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | H2O: ≥2mg/mL |
| Merck | 14,10187 |
| InChIKey | FUXFIVRTGHOMSO-UHFFFAOYSA-N |
| CAS 数据库 | 165800-06-6(CAS DataBase Reference) |
唑来磷酸 用途与合成方法
| Target | Value |
|
Ras
() | |
|
Rho
() |
Zoledronic Acid monohydrate (0.1-1 µM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells.
Zoledronic Acid monohydrate increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells.
Zoledronic Acid monohydrate enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells.
Zoledronic Acid monohydrate inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways.
Zoledronic Acid monohydrate (10-100 µM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells.
Zoledronic Acid monohydrate (10-100 µM; 1-7 days) induces apoptosis in MC3T3-E1 cells.
Zoledronic Acid monohydrate (10-100 µM; 4 days) inhibits cell viability due to the induction of apoptosis.
Zoledronic Acid monohydrate exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1 µM.
Cell Viability Assay
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.02 µM , 0.1 µM, 1 µM, 10 µM, 100 µM |
| Incubation Time: | 1 day, 3 days, 5 days, 7 days |
| Result: | Reduced cells viability at 10 µM and 100 µM. |
Apoptosis Analysis
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.02 µM , 0.1 µM, 1 µM, 10 µM, 100 µM |
| Incubation Time: | 1 days, 4 days, 7 days |
| Result: | Increased the number of early apoptotic cells and late apoptotic or necrotic cells at dose-dependent and time-dependent (high concentrations). |
Western Blot Analysis
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.02 µM , 0.1 µM, 1 µM, 10 µM, 100 µM |
| Incubation Time: | 4 days |
| Result: | Down-regulated the protein level of inactive caspase-3 and up-regulated the protein level of active caspase-3 at the concentrations of 10 and 100 µM. |
Zoledronic Acid monohydrate (0.05 mg/kg; i.p.; weekly; for 3 weeks) increases bone mineral density and content.
Zoledronic Acid monohydrate (0.5-1 mg/kg; i.p.; weekly; for 3 weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties.
| Animal Model: | Five-week-old C57BL6 mice |
| Dosage: | 0.05 mg/kg, 0.5 mg/kg, 1 mg/kg |
| Administration: | Intraperitoneal injection, weekly, for 3 weeks |
| Result: | Inhibited both osteoclast and osteoblasts function and bone remodeling at 0.5 mg/kg and 1 mg/kg. |
唑来磷酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-11 | XW1658000662 | 唑来磷酸一水化合物 | 165800-06-6 | 5G | 544 |
| 2024-11-11 | XW1658000661 | 唑来磷酸一水化合物 | 165800-06-6 | 1G | 146 |
