Riboflavine

Product NameRiboflavine
CAS83-88-5
MFC17H20N4O6
MW376.36
EINECS201-507-1
MOL File83-88-5.mol

Chemical Properties

Melting point	290 °C (dec.)(lit.)
alpha	-135 º (c=5, 0.05 M NaOH)
Boiling point	504.93°C (rough estimate)
Density	1.2112 (rough estimate)
refractive index	-135 ° (C=0.5, JP Method)
Flash point	9℃
storage temp.	2-8°C
solubility	Very slightly soluble in water, practically insoluble in ethanol (96 per cent). Solutions deteriorate on exposure to light, especially in the presence of alkali. It shows polymorphism (5.9).
form	Powder
pka	1.7(at 25℃)
color	Yellow to orange
Odor	Slight odour
PH Range	6
PH	5.5-7.2 (0.07g/l, H2O, 20°C)
Water Solubility	0.07 g/L (20 ºC)
Sensitive	Light Sensitive
Merck	14,8200
BRN	97825
BCS Class	1
Stability	Stable, but light-sensitive. Incompatible with strong oxidizing agents, reducing agents, bases, calcium, metallic salts. May be moisture sensitive.
InChIKey	AUNGANRZJHBGPY-SCRDCRAPSA-N
LogP	-2.009 (est)
CAS DataBase Reference	83-88-5(CAS DataBase Reference)
NIST Chemistry Reference	Riboflavine(83-88-5)
EPA Substance Registry System	Riboflavin (83-88-5)

Safety Information

Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25
Safety Statements	24/25-45-36/37-16
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
RTECS	VJ1400000
F	8-10-21
TSCA	Yes
HS Code	29362300
Hazardous Substances Data	83-88-5(Hazardous Substances Data)
Toxicity	LD50 in rats (g/kg): >10 orally, 5.0 s.c., 0.56 i.p. (Unna, Greslin)

MSDS

Provider	Language
Riboflavin	English
SigmaAldrich	English
ACROS	English
ALFA	English

Usage And Synthesis

Chemical Properties

Riboflavin is moderately soluble in water (10–13 mg/dl) and ethanol but insoluble in ether, chloroform, and acetone. It is soluble but unstable under alkaline conditions.

The catalytic functions of riboflavin are carried out primarily at positions N-1, N-5, and C-4 of the isoalloxazine nucleus. In addition, the methyl group at C-8 participates in covalent bonding with enzyme proteins.

Uses

People most commonly use riboflavin to prevent riboflavin deficiency, for migraine, and for high levels of homocysteine in the blood. It's also used for acne, muscle cramps, and many other conditions, but there is no good scientific evidence to support these other uses.

Side effects

In some people, riboflavin can cause the urine to turn a bright yellow color. It may also cause nausea.

Toxicology

Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Source

Riboflavin is widely found in both plant- and animal-based foods, including milk, meat, eggs, nuts, enriched flour, and green vegetables.

Dosage

When taken by mouth: Riboflavin is likely safe for most people in doses of up to 400 mg daily. In some people, riboflavin can cause the urine to turn a bright yellow color. It may also cause nausea. Pregnancy and breast-feeding: Riboflavin is likely safe when consumed in amounts commonly found in foods. The recommended intake is 1.4 mg daily during pregnancy and 1.6 mg daily during lactation. Children: Riboflavin is likely safe for most children when consumed in amounts commonly found in foods. Higher doses of 100-200 mg daily have also been safely used.