CARBENICILLIN INDANYL SODIUM
26605-69-6 Basic informationMore
- Product Name:CARBENICILLIN INDANYL SODIUM
- Synonyms: Malonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenyl-, 1-(5-indanyl) ester, monosodium salt (8CI) Monosodium indanyl carbenicillin Sodium 5-indanylcarbenicillin Sodium indanylcarbenicillin CARBENICILLIN INDANYL SODIUM (300 MG) 6-yl)-2-phenyl-,1-(5-indanyl)ester,monosodiumsalt carbenicillinindanyl carbenicillinindanylsodium
- CAS:26605-69-6
- MF:C26H26N2O6S.Na
- MW:0
- EINECS:247-845-3
- Mol File:26605-69-6.mol
USE
<p>Carbenicillin indanyl sodium has been shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic.<br/>
Efforts to obtain orally active forms of carbenicillin led to theeventual release of the 5-indanyl ester carbenicillin indanyl,6-[2-phenyl-2-(5-indanyloxycarbonyl)acetamido]penicillanicacid (Geocillin), in 1972. Approximately 40% of theusual oral dose of indanyl carbenicillin is absorbed. After absorption,the ester is hydrolyzed rapidly by plasma and tissueesterases to yield carbenicillin. Thus, although the highlylipophilic and highly protein-bound ester has in vitro activitycomparable with that of carbenicillin, its activity in vivo isdue to carbenicillin. Indanyl carbenicillin thus provides anorally active alternative for the treatment of carbenicillinsensitivesystemic and urinary tract infections caused byPseudomonas spp., indole-positive Proteus spp., and selectedspecies of Gram-negative bacilli.<br>Clinical trials with indanyl carbenicillin revealed a relativelyhigh frequency of GI symptoms (nausea, occasionalvomiting, and diarrhea). It seems doubtful that the highdoses required for the treatment of serious systemic infectionscould be tolerated by most patients. Indanyl carbenicillinoccurs as the sodium salt, an off-white, bitter powderthat is freely soluble in water. It is stable in acid. It should beprotected from moisture to prevent hydrolysis of the ester.</p>
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- Company Name:J & K SCIENTIFIC LTD.
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- Products Intro:Product Name:SodiuM Indanylcarbinicillin
CAS:26605-69-6
Package:500Mg,50Mg More... - CB Index:76
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- Company Name:Beijing Solarbio Science & Tecnology Co., Ltd.
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Package:300mg More... - CB Index:68
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- Company Name:Shenzhen Polymeri Biochemical Technology Co., Ltd.
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- Products Intro:Product Name:SodiuM Indanylcarbinicillin
CAS:26605-69-6
More... - CB Index:58
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- Company Name:AFINE CHEMICALS LIMITED
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- Products Intro:Product Name:CARBENICILLIN INDANYL SODIUM
CAS:26605-69-6
Purity:98%+ Package:Standard or custom package Remarks:excellent quality and reliable supplier - CB Index:58
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- Company Name:Shaanxi Dideu Medichem Co. Ltd
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- Products Intro:Product Name:CARBENICILLIN INDANYL SODIUM USP/EP/BP
CAS:26605-69-6
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer - CB Index:58
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- Company Name:Energy Chemical
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- Products Intro:Product Name:Sodium Indanylcarbinicillin
CAS:26605-69-6
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- Company Name:TargetMol Chemicals Inc.
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- Products Intro:Product Name:Carindacillin sodium
CAS:26605-69-6
Package:2mg/RMB 591;5mg/RMB 997;10mg/RMB 1730 - CB Index:58
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