Verapamil hydrochloride
23313-68-0 Basic informationMore
- Product Name:Verapamil hydrochloride
- Synonyms: CALAN IPROVERATRIL (+/-)-5-[N-(3,4-DIMETHOXYPHENYLETHYL)-METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE 5-[N-(3,4-DIMETHOXYPHENYLETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile hydrochloride ALPHA-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-3,4-DIMETHOXY-ALPHA-(1-METHYLETHYL)BENZENEACETONITRILE HYDROCHLORIDE 5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE (+/-)-VERAPAMIL HYDROCHLORIDE
- CAS:23313-68-0
- MF:C27H39ClN2O4
- MW:491.06
- EINECS:245-579-2
- Mol File:23313-68-0.mol
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USE
Verapamil hydrochloride (VRP) is a phenylalkylamine calcium ion influx inhibitor (calcium antagonist). Verapamil hydrochloride exerts its pharmacologic effects by modulating the influx of ionic through the slow channels of vascular smooth muscle and cardiac cell membranes. It is widely used for the treatment of hypertension, angina pectoris, supraventricular tachycardia, myocardial infraction, and vascular headaches. Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines
The plasma half-life of verapamil hydrochloride is 2–7 hours, which necessitates multiple dosing. After oral administration of VRP to humans, the drug is rapidly absorbed and widely distributed. It is approximately 90% absorbed from the gastrointestinal tract but is subject to considerable first pass metabolism and its bioavailability is around 20–30%. The low bioavailability is owing to the rapid biotransformation in the liver with a biological half-life of 4.0±1.5 hours.
Lastest Price from Verapamil hydrochloride manufacturers
- Verapamil hydrochloride
-
- US $0.00 /KG
- CAS:23313-68-0
- Min. Order: 1KG
- Purity: 99%,USP
- Supply Ability: 500kg/month
- 2023-11-15
- Verapamil hydrochloride
-
- US $1.10 /g
- CAS:23313-68-0
- Min. Order: 1g
- Purity: 99.9 %
- Supply Ability: 100 Tons min
- 2021-08-10
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:VERAPAMIL HYDROCHLORIDE
CAS:23313-68-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15848)
- Company Name:Wuhan Fortuna Chemical Co., Ltd
- Tel:027-027-59207852 13308628970
- Products Intro:Product Name:Verapamil Hcl
CAS:23313-68-0
Purity:99% Package:1kg，25kg More... - CB Index:58
- Related Information:Catalog(2893)
- Company Name:Struchem Co., Ltd.
- Tel:0512-0512-63009836 15365350169
- Products Intro:Product Name:Verapamil hydrochloride
CAS:23313-68-0
Purity:98 Package:100g - CB Index:60
- Related Information:Catalog(3989)
- Company Name:Shanghai Qiao Chemical Science Co., Ltd
- Tel:021-58892003
- Products Intro:Product Name:Verapamil hydrochloride
CAS:23313-68-0
Purity:99% Package:1kg/ - CB Index:65
- Related Information:Catalog(5881)