Apalutamide
956104-40-8 Basic informationMore
- Product Name:Apalutamide
- Synonyms: ARN-509 AR509 AR509 100G ARV-509 ARN-509;ARN 509; ARN509 4-(7-(4-Cyano-3-(trifluoromethyl)phenyl)-8-hydroxy-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-f AR509/AR-509 ARN
- CAS:956104-40-8
- MF:C21H15F4N5O2S
- MW:477.43
- EINECS:807-449-9
- Mol File:956104-40-8.mol
-
USE
ARN-509 (10 mg/kg/d, oral) inhibits tumor growth with decreased proliferative index and increased apoptotic rate in castrate male immunodeficient mice harboring LNCaP/AR-luc xenograft tumors. ARN-509 dose dependently inhibits tumor growth with highest efficacy at dose of 30 mg/kg/day in castrate male immunodeficient mice harboring LNCaP/AR-luc xenograft tumors. ARN-509 dosed at 10 mg/kg/d for 28 days results in a 3-fold reduction in prostates weight associated with lacking glandular secretory activity and 1.7-fold reduction in epididymis weight in adult male dogs. ARN-509 (10 mg/kg/d, oral) inhibits cell proliferation of prostate tissues in adult male dogs. ARN-509 is safe and well tolerated in 24 patients with metastatic CRPC who has progressed on prior treatments and peak plasma concentrations occurred 2 to 3 hours after administration. ARN-509 results in durable PSA declines at doses ranging from 30 to 300 mg in patients with metastatic CRPC. ARN-509 shows powerful anti-cancer activity and induces durable remissions long after therapy completion in castrate resistant prostate cancer mouse models.
Lastest Price from Apalutamide manufacturers
- Apalutamide
-
- US $0.00 /Kg/Bag
- CAS:956104-40-8
- Min. Order: 2Kg/Bag
- Purity: 0.99
- Supply Ability: 20 tons
- 2024-12-18
- Apalutamide
-
- US $0.00 /Kg/Bag
- CAS:956104-40-8
- Min. Order: 2Kg/Bag
- Purity: 0.99
- Supply Ability: 20 tons
- 2024-12-18
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- Company Name:Cangzhou Kangrui Medical Technology Co., LTD
- Tel: 18632776803
- Products Intro:Product Name:Apalutamide
CAS:956104-40-8
Purity:99% HPLC Package:5G;10G;100G - CB Index:58
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- Company Name:ChemFuture PharmaTech (Jiangsu) Ltd
- Tel:5108538618
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CAS:956104-40-8
Remarks:CFP8370 More... - CB Index:65
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- Company Name:Changzhou Yongfeng Biomedicine Co. Ltd.
- Tel: 15006117673
- Products Intro:Product Name:ARN-509
CAS:956104-40-8
Purity:98 Package:1g 10g 100g 1kg More... - CB Index:58
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- Company Name:Hangzhou Xinbaisi Biomedical Co., Ltd.
- Tel: 13325818654
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CAS:956104-40-8
Purity:98% Package:5g;100g;1kg;100kg More... - CB Index:58
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- Company Name:Sichuan Qingmu Pharmaceutical Co., Ltd.
- Tel:028-87827187 13419034739
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CAS:956104-40-8
Purity:In-House; HPLC Package:1KG; 5KG;10KG - CB Index:60
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- Company Name:Junyu Chemexpress Co., Ltd.
- Tel:0731-88036271 13723890100
- Products Intro:Product Name:Apalutamide
CAS:956104-40-8
Purity:99.50% Package:1g,25g,50g,100g,200g,500g,1kg,5kg - CB Index:58
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- Company Name:Shanghai Youna Biopharmaceutical Co., Ltd
- Tel: 18164002430
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CAS:956104-40-8
- CB Index:58
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- Company Name:Zhengzhou Runkai Pharmaceutical Technology Co., Ltd
- Tel:19137044811; 19137644811
- Products Intro:Product Name:ARN-509
CAS:956104-40-8
Purity:99% Package:5g - CB Index:58
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