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Paliperidone

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144598-75-4 Basic informationMore
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Paliperidone, (±)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one(Invega), is essentially insoluble in water and is available asextended-release tablets. Paliperidone is delivered at a constantrate using an osmotic drug release device (OsmoticRelease Oral Systems [OROS]). The absolute bioavailabilityof paliperidone is 28%, and studies in healthy subjects on ahigh-fat, high-calorie meal showed an increase in AUC.Paliperidone is 74% bound to plasma proteins. After a single,1-mg dose of C-paliperidone, 59% of the dose was excretedin the urine as unchanged drug, and 32% of the dose was recoveredas metabolites. Most of the drug (80%) is excreted bythe kidneys. Paliperidone is metabolized by dealkylation, hydroxylation,dehydrogenation, and scission of the benzoxazolering. None of these metabolic pathways account for morethan 10% of the dose. The terminal elimination half-life ofpaliperidone is 23 hours.
Lastest Price from Paliperidone manufacturers
  • Paliperidone
  • US $0.00-0.00/Kg/Bag
  • CAS:144598-75-4
  • Min. Order: 1Kg/Bag
  • Purity: 0.99
  • Supply Ability: 20 tons
  • 2024-08-02
  • Paliperidone
  • US $0.00 /kg
  • CAS:144598-75-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 10000kg
  • 2024-05-16

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  • Company Name:Zhuzhou focus pharmaceutical technology co., LTD
  • Tel: +86-13776644403
  • Products Intro:Product Name:Paliperidone
    CAS:144598-75-4
    Purity:98% Package:1g;5g;10g;25g;50g;100g;bulk More...
  • CB Index:58
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  • Company Name:NanJing Vtrying Pharmatech Co.,Ltd
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    Purity:99.5% HPLC Package:10g;100g;1kg;5kg;25kg
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  • Company Name:Hefei Lifeon Pharmaceutical Co.Ltd.
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  • Company Name:J & K SCIENTIFIC LTD.
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  • Products Intro:Product Name:Paliperidone, 99%, a potent D2 and 5-HT2A antagonist
    CAS:144598-75-4
    Purity:99% Package:10MG;50MG More...
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  • Company Name:Chemvon Biotechnology Co., Ltd
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  • Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
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    Purity:>97.0%(T) Package:200Mg;1g Remarks:P1897 More...
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