FALECALCITRIOL

• Product Name:FALECALCITRIOL
• Synonyms: (+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1α,3β,25-triol 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1α,3β,5Z,7E)- Flocalcitriol Flocalcitrol Fulstan Ro 23-4194 ST 630
• CAS:83805-11-2
• MF:C27H38F6O3
• MW:524.58
• EINECS:
• Mol File:83805-11-2.mol
• 

Falecalcitriol, previously known as flocalcitrol, was launched by several codevelopers in Japan for the treatment of secondary hyperthyroidism (SHPT). This hexafluorinated analog of 1α,25-dihydroxyvitamin D3 (calcitriol), the hormonally active form of vitamin D3, can be obtained by several different synthetic routes from a conveniently protected cholestenol, a key step being an aldol reaction with hexafluoroacetone. Falecalcitriol is several times more active than 1,25(OH)₂D₃ in regulating the proliferation of parathyroid cells and parathyroid hormone (PTH) synthesis that are believed to be mediated through binding to VDR, a nuclear receptor for vitamin D; furthermore, it was proposed that a bioactive 23S-hydroxylated metabolite, resistant to further metabolism, contributes to the retention of an active compound for longer in cells and so, to significantly lengthen the duration of action. In a comparative clinical study conducted in hemodialysis patients with moderate to severe SHPT, falecalcitriol was found to be more active than alfacalcidol in suppressing parathyroid hormone without triggering hypercalcemia.

• Company Name:Wuhan Wsem Biological Co., Ltd.
• Tel:027-83778876 13667159345
• Products Intro:Product Name:Falecalcitriol
  CAS:83805-11-2
  Purity:99% Package:100mg/RMB 35000;200mg/RMB 50000
• CB Index:55
• Related Information:Catalog(1990)

• Company Name:Chemvon Biotechnology Co., Ltd
• Tel:021-50790412
• Products Intro:Product Name:Falecalcitriol
  CAS:83805-11-2
  Purity:98% Package:1g, 10g, 100g, 200g, 1kg, 5kg More...
• CB Index:57
• Related Information:Catalog(371)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
  CAS:83805-11-2
  Purity:98% HPLC Package:10mg;50mg;100mg;500mg;1g Remarks:Biochemical Reagents; Pharmaceutical Intermediates More...
• CB Index:61
• Related Information:Catalog(6008)

• Company Name:ChemStrong Scientific Co.,Ltd
• Tel:0755-0755-66853366 13670046396
• Products Intro:Product Name:Falecalcitriol
  CAS:83805-11-2
  Purity:95% HPLC Package:10mg;25mg;50mg;100mg More...
• CB Index:56
• Related Information:Catalog(18046)

• Company Name:Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.
• Tel: 15981924004
• Products Intro:Product Name:Falecalcitriol
  CAS:83805-11-2
  Purity:98 Package:1kgs;10kgs;100kgs
• CB Index:56
• Related Information:Catalog(1872)