Pyrimethamine
58-14-0 Basic informationMore
- Product Name:Pyrimethamine
- Synonyms: 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine [2-amino-5-(4-chlorophenyl)-6-ethyl-pyrimidin-4-yl]amine Pyrimethamine,5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine Pyrimethamine (200 mg) PyriMethaMine,darapriM 5-(p-chlorophenyl)-6-ethyl-4-pyrimidinediamine BW 50-63 bw50-63
- CAS:58-14-0
- MF:C12H13ClN4
- MW:248.71
- EINECS:200-364-2
- Mol File:58-14-0.mol
USE
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine.<br />
Pyrimethamine is a dihydrofolate reductase inhibitor, like the biguanides, and is structurally related to trimethoprim. It is seldom used alone. Pyrimethamine in fixed combinations with dapsone or sulfadoxine is used for treatment and prophylaxis of chloroquine-resistant falciparum malaria. The synergistic activities of pyrimethamine and sulfonamides are similar to those of trimethoprim/sulfonamide combinations. Resistant strains of Plasmodium falciparum have appeared world wide. Prophylaxis against falciparum malaria with pyrimethamine alone is therefore not recommended. Most strains of Plasmodium vivax have remained sensitive. Pyrimethamine is also used in combination with a sulfonamide for the treatment of Toxoplasmosis. It is slowly absorbed from the gastrointestinal tract with peak plasma levels 4–6 hours after dosing. Pyrimethamine is bound to plasma proteins and is extensively metabolized before excretion. Its elimination half-life is 3–5 days.
Lastest Price from Pyrimethamine manufacturers
- Pyrimethamine
- US $150.00 /kg
- CAS:58-14-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 500kg
- 2024-12-25
- Pyrimethamine
- US $0.00-0.00/Kg/Drum
- CAS:58-14-0
- Min. Order: 1KG
- Purity: 99%-101%; BP/USP
- Supply Ability: 500KGS
- 2024-12-13
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- Company Name:Hubei Weideli Chemical Reagent Co.,Ltd.
- Tel: 13339985473
- Products Intro:Product Name:Pyrimidine ethylamine
CAS:58-14-0
Purity:99% HPLC Package:1KG 5KG 10KG 25KG 50KG 100KG 500KG 武汉鼎信通大量现货供应 高纯度99%+ 优势现货 下单当天可发货 长期稳定供货 订 - CB Index:58
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- Tel:183-0212-4410 18302124410
- Products Intro:Product Name:Pyrimethamine
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Purity:98% Package:1g;100g;1kg - CB Index:58
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- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Pyrimethamine, 98%
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Purity:98% Package:1G;5G More... - CB Index:76
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- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:PyriMethaMine;5-(4-Chlorophenyl)-6-ethyl-2,4-pyriMidinediaMine
CAS:58-14-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Tel:021-67121386
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Purity:98.0% LC&T Package:1G,5G More... - CB Index:81
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- Company Name:Beijing HwrkChemical Technology Co., Ltd
- Tel:010-89508211 18501085097
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CAS:58-14-0
Purity:99.00% Package:100g Remarks:HWG10328 - CB Index:55
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- Tel:021-021-58432009 400-005-6266
- Products Intro:Product Name:Pyrimethamine
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Purity:98% Package:5g;25g;100g;1g;100mg;10mg;250mg;500mg;50mg;1kg Remarks:NULL More... - CB Index:61
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