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Pyrimethamine

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58-14-0 Basic informationMore
USE
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine.<br /> Pyrimethamine is a dihydrofolate reductase inhibitor, like the biguanides, and is structurally related to trimethoprim. It is seldom used alone. Pyrimethamine in fixed combinations with dapsone or sulfadoxine is used for treatment and prophylaxis of chloroquine-resistant falciparum malaria. The synergistic activities of pyrimethamine and sulfonamides are similar to those of trimethoprim/sulfonamide combinations. Resistant strains of Plasmodium falciparum have appeared world wide. Prophylaxis against falciparum malaria with pyrimethamine alone is therefore not recommended. Most strains of Plasmodium vivax have remained sensitive. Pyrimethamine is also used in combination with a sulfonamide for the treatment of Toxoplasmosis. It is slowly absorbed from the gastrointestinal tract with peak plasma levels 4&ndash;6 hours after dosing. Pyrimethamine is bound to plasma proteins and is extensively metabolized before excretion. Its elimination half-life is 3&ndash;5 days.
Lastest Price from Pyrimethamine manufacturers
  • Pyrimethamine
  • US $0.00-0.00/Kg/Drum
  • CAS:58-14-0
  • Min. Order: 1KG
  • Purity: 99%-101%; BP/USP
  • Supply Ability: 500KGS
  • 2024-11-22
  • Pyrimethamine
  • US $235.00 /KG
  • CAS:58-14-0
  • Min. Order: 25KG
  • Purity: 98%
  • Supply Ability: 1-10mt
  • 2024-11-14

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