Pyrimethamine
58-14-0 Basic informationMore
- Product Name:Pyrimethamine
- Synonyms: 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine [2-amino-5-(4-chlorophenyl)-6-ethyl-pyrimidin-4-yl]amine Pyrimethamine,5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine Pyrimethamine (200 mg) PyriMethaMine,darapriM 5-(p-chlorophenyl)-6-ethyl-4-pyrimidinediamine BW 50-63 bw50-63
- CAS:58-14-0
- MF:C12H13ClN4
- MW:248.71
- EINECS:200-364-2
- Mol File:58-14-0.mol
-
USE
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine.<br />
Pyrimethamine is a dihydrofolate reductase inhibitor, like the biguanides, and is structurally related to trimethoprim. It is seldom used alone. Pyrimethamine in fixed combinations with dapsone or sulfadoxine is used for treatment and prophylaxis of chloroquine-resistant falciparum malaria. The synergistic activities of pyrimethamine and sulfonamides are similar to those of trimethoprim/sulfonamide combinations. Resistant strains of Plasmodium falciparum have appeared world wide. Prophylaxis against falciparum malaria with pyrimethamine alone is therefore not recommended. Most strains of Plasmodium vivax have remained sensitive. Pyrimethamine is also used in combination with a sulfonamide for the treatment of Toxoplasmosis. It is slowly absorbed from the gastrointestinal tract with peak plasma levels 4–6 hours after dosing. Pyrimethamine is bound to plasma proteins and is extensively metabolized before excretion. Its elimination half-life is 3–5 days.
Lastest Price from Pyrimethamine manufacturers
- Pyrimethamine
-
- US $0.00 /kg
- CAS:58-14-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg
- 2024-04-11
- Pyrimethamine
-
- US $0.00 /kg
- CAS:58-14-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
- 2024-04-08
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- Company Name:Hubei Weideli Chemical Reagent Co.，Ltd.
- Tel: 13339985473
- Products Intro:Product Name:Pyrimethamine
CAS:58-14-0
Purity:99% Package:1KG;5KG;10KG - CB Index:58
- Related Information:Catalog(3460)
- Company Name:Shanghai Hanlin biology science and technology co., ltd
- Tel:131-6639-0736
- Products Intro:Product Name:Pyrimethamine
CAS:58-14-0
Purity:98% Package:1g；100g；1kg - CB Index:58
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Pyrimethamine, 98%
CAS:58-14-0
Purity:98% Package:1G;5G More... - CB Index:76
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:PyriMethaMine;5-(4-Chlorophenyl)-6-ethyl-2,4-pyriMidinediaMine
CAS:58-14-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:Pyrimethamine
CAS:58-14-0
Purity:98.0% LC&T Package:1G,5G More... - CB Index:81
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- Company Name:BeiJing Hwrk Chemicals Limted
- Tel:0757-86329057 18501085097
- Products Intro:Product Name:Pyrimethamine
CAS:58-14-0
Purity:99.00% Package:100g Remarks:HWG10328 - CB Index:55
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- Company Name:Energy Chemical
- Tel:021-021-58432009 400-005-6266
- Products Intro:Product Name:Pyrimethamine
CAS:58-14-0
Purity:98% Package:5g;25g;100g;1g;100mg;10mg;250mg;500mg;50mg;1kg Remarks:NULL More... - CB Index:61
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