HIRUDIN
8001-27-2 Basic informationMore
- Product Name:HIRUDIN
- Synonyms: hirudex recombinanthirudin HIRUDIN RECOMBINANT DESULFATO-HIRUDIN DESULFO-HIRUDIN NATIVE HIRUDIN [TYR63]HIRUDIN (HV1), LEECH (63-tyrosine)hirudin (hv1),leech,rec. F. yeast
- CAS:8001-27-2
- MF:C287H440N80O113S7
- MW:7043.4877
- EINECS:232-279-1
- Mol File:8001-27-2.mol
-
USE
Refludan was launched in Germany for heparin-associated
thrombocytopenia. Originally isolated from the saliva of leeches (Hirudo medicinalis),
the gene for recombinant hirudin was synthesized and expressed in Saccharomyces
cerevisiae. The isolated protein is 65 amino acids differing from the native protein by
the first two amino acids (Leu1 and Thr2) and Tyr63 is not sulfated, while it does retain
the three disulfide bonds. Refludan is a potent, specific and almost irreversible
inhibitor of thrombin with which it forms a 1:1 complex. The N-terminal domain binds
to the active catalytic site of thrombin, while the C-terminal end binds to the anion
binding exosite (fibrinogen binding cleft). It has several advantages over heparin: it
can inhibit thrombin bound to extracellular matrices, does not require antithrombin Ⅲ
as a cofactor, is not inhibited by activated platelet nor increases platelet activity, and is
a pure, single compound with a single mechanism of action. It is useful for myocardial
infarcts, unstable angia and cardiovascular events. Heparin treatment can be inhibited
by platelets activated by the Fc fragment of antibodies developed to the antigen of
heparin-platelet factor 4. A corresponding inactivation of Refuldan is not known.
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- Company Name:Shanghai Hanhong Scientific Co.,Ltd.
- Tel:021-54306202 13764082696
- Products Intro:CAS:8001-27-2
More... - CB Index:64
- Related Information:Catalog(42959)
- Company Name:Wuhan DKY Technology Co.,Ltd.
- Tel:27-81302488 18007166089
- Products Intro:CAS:8001-27-2
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- Related Information:Catalog(2024)
- Company Name:Hubei Jusheng Technology Co.,Ltd
- Tel:027-59599241 18871490274
- Products Intro:Product Name:HIRUDIN
CAS:8001-27-2
Purity:99% HPLC Package:25KG;200KG;5KG;1KG;1T More... - CB Index:58
- Related Information:Catalog(9957)
- Company Name:Sigma-Aldrich
- Tel:021-61415566 800-8193336
- Products Intro:Product Name:Hirudin recombinant from yeast
CAS:8001-27-2
Purity:lyophilized powder, white, >1500 U/vial Package:1EA Remarks:94581-1EA More... - CB Index:80
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- Company Name:Chengdu Youngshe Chemical Co., Ltd.
- Tel:+86-17380623303 +86-17380623303
- Products Intro:Product Name:Recombinant Hirudin
CAS:8001-27-2
Package:1mg - CB Index:58
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- Company Name:Hangzhou Peptidego Biotech Co.,Ltd.
- Tel:0571-87213919
- Products Intro:CAS:8001-27-2
Purity:95% or 98% Package:1mg;5mg;10mg;50mg;100mg,1g or according to customer's detail requirement. More... - CB Index:58
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- Company Name:Shanghai Tube Pharmaceutical Co., Ltd.
- Tel:021-54338626 18017892860
- Products Intro:Product Name:recombinanthirudin
CAS:8001-27-2
Purity:90%-97% Package:1g，5g，10g，100g More... - CB Index:58
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