Niraparib
1038915-60-4 Basic informationMore
- Product Name:Niraparib
- Synonyms: MK-4827,(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide Niraparib 2-[4-((3S)-3-Piperidinyl)phenyl]-2H-indazole-7-carboxamide MK4827 (Niraparib) 2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]- (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrocholoride 2-[4-(3S)piperidin-3-ylphenyl]-2H-indazol-7-carboxamide 2-[4-[(3s)-piperidin-3-yl]phenyl]indazole-7-carboxamide
- CAS:1038915-60-4
- MF:C19H20N4O
- MW:320.39
- EINECS:
- Mol File:1038915-60-4.mol
-
USE
The synthesis and initial pharmacology of niraparib have been published. Niraparib has affinity for PARP 1 and 2 inhibition (IC50 = 3.8 and 2.1 nM, respectively) and inhibits the proliferation of cancer cells with mutant BRCA1 and BRCA2 with IC50 values in the 10–100 nM range in vitro. Niraparib demonstrated efficacy as a single agent in a xenograft model of BRCA1-deficient cancer. Niraparib has also been reported to act as a preclinical radiosensitiser and has entered into clinical oncology trials.
Lastest Price from Niraparib manufacturers
- Niraparib
-
- US $8.00-0.80/kg
- CAS:1038915-60-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 2024-04-08
- Niraparib
-
- US $0.00-0.00/kg
- CAS:1038915-60-4
- Min. Order: 1kg
- Purity: 99%, Single impurity＜0.1
- Supply Ability: 1 ton
- 2023-12-26
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- Company Name:Taizhou Ruishinuo Pharmaceutical Technology Co., Ltd.
- Tel:0523-86848872 19952992164
- Products Intro:Product Name:Niraparib
CAS:1038915-60-4
Purity:99.5+% Package:100g,1kg,10kg More... - CB Index:58
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- Company Name:Jiangsu yize medical technology co. LTD
- Tel: 18550739526
- Products Intro:Product Name:MK-4827, Niraparib
CAS:1038915-60-4
Purity:99; 99%ee Package:1G; 5G; 25G; 100G; 1KG More... - CB Index:58
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- Company Name:Guangzhou Zhiya Chemdrugs Co.,Ltd
- Tel: 18122150900
- Products Intro:CAS:1038915-60-4
More... - CB Index:55
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- Company Name:Nanjing Qiya Pharmaceutical Co., Ltd.
- Tel:025-85451006; 18795969897
- Products Intro:Product Name:Niraparib
CAS:1038915-60-4
Purity:99.5%HPLC Package:1g;10g;100g;1kg More... - CB Index:58
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- Company Name:Anhui nuoquan pharmaceutical co. LTD
- Tel:0556-5032870 15705561919
- Products Intro:Product Name:niraparib
CAS:1038915-60-4
Purity:99%，Single impurity less than 0.15% Package:10g,100g More... - CB Index:55
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- Company Name:CHANGZHOU PHARMACEUTICAL FACTORY
- Tel:519-88821493 18915891730
- Products Intro:Product Name:Niraparib
CAS:1038915-60-4
Purity:99% HPLC Package:1kg - CB Index:58
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- Company Name:Chembest Research Laboratories Limited
- Tel:021-20908456
- Products Intro:Product Name:Niraparib (MK4827)
CAS:1038915-60-4
Purity:98%+ HPLC Package:50mg;100mg;500mg;1g;5g;10g Remarks:Biochemical Reagents; Pharmaceutical Intermediates More... - CB Index:61
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