Indacaterol
312753-06-3 Basic informationMore
- Product Name:Indacaterol
- Synonyms: Indacaterol 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one (R)-5-(2-(5,6-diethyl-2,3-dihydro-1H-inden-2-ylaMino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, Maleate salt Arcapta 5-[2-(5,6-Diethyl-2,3-dihydro-1H-inden-2-ylaMino)-(1R)-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one (R)-5-(2-(5,6-Diethyl-2,3-dihydro-1H-inden-2-ylamino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)- 2(1H)-Quinolinone,5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy- Indacaterol-d3
- CAS:312753-06-3
- MF:C24H28N2O3
- MW:392.49
- EINECS:691-091-1
- Mol File:312753-06-3.mol
-
USE
Inhaled β2 adrenoceptor agonists are effective in the management of
asthma and COPD, primarily through their bronchodilating properties.
These drugs induce bronchodilation by causing direct relaxation of airway smooth muscle through activation of adenylate cyclase, which in
turn increases intracellular cAMP levels.
Indacaterol is the
newest β2 agonist to reach the market. It is an ultra-long-acting agent
with a duration of action suitable for once-a-day dosing. Indacaterol is
supplied as an aerosol formulation of its maleate salt and is administered
via a dry powder inhaler device.
It is specifically approved for once-daily
maintenance treatment of airflow obstruction in adult patients with
COPD. In preclinical models, indacaterol is close to a full agonist at the
human b2 adrenoceptor (Emax = 73 ± 1% of isoprenaline′s maximal
effect, pEC<sub>50</sub> = 8.06 ±0.02) while salmeterol displays only partial efficacy
(38 ±1%). The functional selectivity profile of indacaterol over β1 human
adrenoceptors is similar to that of formoterol, whereas its β3 adrenoceptor selectivity profile is similar to that of formoterol and salbutamol.
Lastest Price from Indacaterol manufacturers
- Indacaterol
-
- US $2.00 /kg
- CAS:312753-06-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 80KG/M
- 2024-11-22
- Indacaterol
-
- US $70.00-700.00/kg
- CAS:312753-06-3
- Min. Order: 10kg
- Purity: 0.99
- Supply Ability: 20tons
- 2024-08-27
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- Company Name:Jinan Billion Pharmaceutical Technology Co., Ltd
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CAS:312753-06-3
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- Company Name:Chembest Research Laboratories Limited
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- Company Name:Changzhou Joyous Chemical Co., Ltd.
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CAS:312753-06-3
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