AZD-8055
1009298-09-2 Basic informationMore
- Product Name:AZD-8055
- Synonyms: AZD 8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol AZD8055, >=98% Propanoic acid, 2,2-dimethyl-, [5-(2,4-dichloropyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl]methyl ester (5-{2,4-dichloropyrido[2,3-d]pyriMidin-7-yl}-2-Methoxyphenyl)Methyl 2,2-diMethylpropanoate [5-[2,4-Bis((3S)-3-MethylMorpholin-4-yl)pyrido[ 5-[2,4-Bis[(3S)-3-Methyl-4-Morpholinyl]pyrido[2,3-d]pyriMidin-7-yl]-2-MethoxybenzeneMethanol CCG 168 AZD8055,AZD-8055
- CAS:1009298-09-2
- MF:C25H31N5O4
- MW:465.54
- EINECS:
- Mol File:1009298-09-2.mol
-
USE
A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphoryla
tion of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dep
endent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S
6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.
Lastest Price from AZD-8055 manufacturers
- AZD-8055
-
- US $7.00 /KG
- CAS:1009298-09-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: JD 495
- 2019-09-02
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:AZD-8055, 98%
CAS:1009298-09-2
Purity:98% Package:10MG More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:AZD8055
CAS:1009298-09-2
Remarks:C13352 More... - CB Index:61
- Related Information:Catalog(6005)
- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:AZD-8055
CAS:1009298-09-2
Purity:>98%,ATPmTOR Package:50MG More... - CB Index:58
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