Selumetinib

• Product Name:Selumetinib
• Synonyms: ARRY 142886 AZD 6244 Selumetinib AZD624 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-car Selumetinib 5-(4-Bromo-2-chlorophenylamino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide 6-(4-Bromo-2-chlorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide SeluMatinib(5-[(4-BroMo-2-chlorophenyl)aMino]-4-fluoro-N-(2-hydroxyethoxy)-1-Methyl-1H-benziMidazole-6-carboxaMide
• CAS:606143-52-6
• MF:C17H15BrClFN4O3
• MW:457.68
• EINECS:207-313-3
• Mol File:606143-52-6.mol
• 

In phase II clinical trials of radioiodine-refractory papillary thyroid carcinoma, 39 patients took daily oral doses of Selumetinib (100mg bid) for 28 days; results showed that 21 patients’ conditions stabilized (54%), 11 patients’ conditions worsened (28%), 49% patients’ conditions were stable for 16 weeks, 36% patients’ conditions were stable for 24 weeks, and survival terms did not progress to 32 weeks. Negative reactions mainly consisted of rashes (59%), diarrhea (44%), and weakness (41%). Some studies found that after treating 20 patients with thyroid cancer with Selumetinib (75mg bid) for 4 weeks, Selumetinib increased the iodine uptake and retention of patients with radioiodine-refractory papillary thyroid carcinoma. In a blind and random comparative study between a Selumetinib and Docetaxel (DOC) combination treatment group and DOC and placebo treatment group for 87 mutant NSCLSC patients, survival times were 9.4 months and 5.2 months, PFS were 5.3 months and 2.1 months, RR were 37% and 0%, thus showing dramatic differences. Selumetinib’s main negative reactions include neutrophil depletion, dermatitis, and respiratory failure.

• Selumetinib
• 
• US $0.00-0.00/g
• CAS:606143-52-6
• Min. Order: 10g
• Purity: 99%
• Supply Ability: 1kg
• 2024-11-08

• Selumetinib
• 
• US $0.00 /KG
• CAS:606143-52-6
• Min. Order: 1KG
• Purity: 98%
• Supply Ability: 1000KGS
• 2024-08-15

• Company Name:WuYan Pharmaceutical Technology (Shanghai) Co., Ltd.
• Tel:021-61001086 13671938079
• Products Intro:Product Name:AZD6244
  CAS:606143-52-6
  Purity:99% HPLC Package:1g;10g;100g More...
• CB Index:55
• Related Information:Catalog(104)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Selumetinib, 99%, a highly selective MEK1 inhibitor
  CAS:606143-52-6
  Purity:99% Package:1G;250MG;50MG More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:SeluMetinib (AZD6244)
  CAS:606143-52-6
  Remarks:C14159 More...
• CB Index:61
• Related Information:Catalog(6005)

• Company Name:Beijing HwrkChemical Technology Co., Ltd
• Tel:010-89508211 18501085097
• Products Intro:Product Name:Selumetinib
  CAS:606143-52-6
  Purity:97.00% Package:1g
• CB Index:55
• Related Information:Catalog(8418)