macitentan

• Product Name:macitentan
• Synonyms: N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)-oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfami macitentan N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide ACT 064992 ACT-064992 ACT-064992 / ACT064992 Macitentan, >=99% SulfaMide,N-[5-(4-broMophenyl)-6-[2-[(5-broMo-2-pyriMidinyl)oxy]ethoxy]-4-pyriMidinyl]-N'-propyl-
• CAS:441798-33-0
• MF:C19H20Br2N6O4S
• MW:588.27
• EINECS:1308068-626-2
• Mol File:441798-33-0.mol
• 

Macitentan (also known as ACT-064992) received US FDA approval in October 2013 for the treatment of pulmonary arterial hypertension (PAH) (WHO group I) to delay disease progression. Treatment options include phosphodiesterase type 5 inhibitors, prostacyclins, and the endothelin receptor antagonists bosentan and ambrisentan. Macitentan was discovered through SAR studies starting with the bosentan structure with three main goals: (1) to increase potency for both endothelin receptor A and B (ET_A and ET_B) subtypes; (2) to improve tissue distribution to reach the target receptors; and (3) to avoid bile salt transport inhibition. Starting with the bosentan sulfonamido-pyrimidinyl central core, potency was increased 10-fold via incorporation of a bromopyrimidinyl ethylene glycol ether, as found in the clinical endothelin antagonist, T-0201. An aryl ether in bosentan was replaced with the bromophenyl group in macitentan, and a substituent on the 2-position of the central pyrimidine was replaced with hydrogen. Several sulfonamides and alkyl sulfamates were explored, with the propylsulfamate providing the best combination of in vitro potency, especially for ETB antagonism, and in vivo efficacy.

• Macitentan
• 
• US $0.00 /g
• CAS:441798-33-0
• Min. Order: 1g
• Purity: More Than 99%
• Supply Ability: 100kg/Month
• 2024-12-25

• Macitentan.
• 
• US $0.00 /g
• CAS:441798-33-0
• Min. Order: 1g
• Purity: More Than 99%
• Supply Ability: 100kg/Month
• 2024-12-25

• Company Name:Hangzhou XunDa Bio-Technology Co., Ltd.
• Tel:0571-86932585
• Products Intro:Product Name:Macitentan
  CAS:441798-33-0
  Purity:99% Package:25kg More...
• CB Index:58
• Related Information:Catalog(41)

• Company Name:Chengdu Climb Pharmaceutical Technology Co., Ltd.
• Tel:028-87608726 13540107218
• Products Intro:Product Name:Macitentan
  CAS:441798-33-0
  Purity:99% Package:5KG;1KG More...
• CB Index:58
• Related Information:Catalog(104)

• Company Name:EASON Chemical Co., LIMITED
• Tel:0576-0576-89232655 13566878689
• Products Intro:Product Name:macitentan; N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide
  CAS:441798-33-0
  Purity:99% Package:克至百公斤级以上 More...
• CB Index:58
• Related Information:Catalog(37)

• Company Name:Anhui Qiushi Medical Technology Co., Ltd
• Tel: 15005516438
• Products Intro:Product Name:macitentan
  CAS:441798-33-0
  Purity:99%；医药级 Package:10kg
• CB Index:58
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• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Macitentan
  CAS:441798-33-0
  Package:100Mg,25Mg,5Mg More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N-propylsulfamide
  CAS:441798-33-0
  Purity:98% HPLC Package:5g;10g Remarks:Biochemical Reagents; Pharmaceutical Intermediates More...
• CB Index:61
• Related Information:Catalog(6005)

• Company Name:Beijing HwrkChemical Technology Co., Ltd
• Tel:010-89508211 18501085097
• Products Intro:Product Name:macitentan
  CAS:441798-33-0
  Purity:95.00% Package:1g
• CB Index:55
• Related Information:Catalog(8418)