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161973-10-0

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161973-10-0 Basic informationMore
USE
Esomeprazole magnesium,S-bis(5-rnethoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-l-yl) magnesiumtrihydrate (Nexium), is the S-enantiomer ofomeprazole. The benzimidazole PPIs contain a chiral sulfuratom that form an enantiomeric pair that is stable andinsoluble under standard conditions. The S-isomer ofomeprazole has slightly greater PPI activity, and its intrinsicclearance is approximately three times lower thanthat of R-omeprazole (15 vs. 43μL/min). The lowerclearance of S-omeprazole is related to slower metabolicclearance by the CYP2C19 isozyme. Although Romeprazoleis primarily transformed to the 5-hydroxymetabolite, the S-isomer is metabolized by O-demethylationand sulfoxidation, which contribute little to intrinsicclearance.
Lastest Price from Esomeprazole magnesium manufacturers
  • Esomeprazole magnesium
  • US $1.00-1.00/Kg/Bag
  • CAS:161973-10-0
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • 2021-07-20

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  • Company Name:Chembest Research Laboratories Limited
  • Tel:021-20908456-
  • Products Intro:Product Name:EsoMeprazole MagnesiuM
    CAS:161973-10-0
    Remarks:C13643 More...
  • CB Index:61
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  • Company Name:Nanjing Chemlin Chemical Co., Ltd
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  • Company Name:Shanghai Hanhong Scientific Co.,Ltd.
  • Tel:021-54302127 021-54306202-
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    CAS:161973-10-0
    Purity:0.97 Remarks:AB07552 More...
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  • Company Name:XiaoGan ShenYuan ChemPharm co,ltd
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