Loperamide

• Product Name:Loperamide
• Synonyms: 4-[4-Chlorophenyl]-4-hydroxy-N, N-dimethyl-α,α-diphenyl-1-piperidinebutanamide 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-,-diphenyl-1-p-piperidinebutanamide LOPERAMIDE 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-di(phenyl)butanamide 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N DIMETHYL-A,A DIPHENYL-1-PEIPERIDINE BUTANAMIDEHCL 4-(4-chlorophenyl)-n,n-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidineb 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide
• CAS:53179-11-6
• MF:C29H33ClN2O2
• MW:477.04
• EINECS:258-416-5
• Mol File:53179-11-6.mol
• 

Loperamide (Imodium) is a 4-phenylypiperidine with amethadone-like structure attached to the piperidine nitrogen. It acts as an antidiarrheal by directly binding tothe opiate receptors in the gut wall. Loperamide inhibitsacetylcholine and prostaglandin release, decreasing peristalsisand fluid secretion thus increasing the GI transit time andreducing the volume of fecal matter.Loperamide is sufficiently lipophilic to cross the blood-brain barrier, yet itdisplays no CNS-opioid effects. The reason for this is that itis actively pumped out of the brain via the P-glycoproteinpump (MDR1). Knockout mice with the P-glycoproteinpump genetically removed were given radiolabeled loperamideand sacrificed 4 hours later. The [³H]loperamideconcentrations were measured and compared with wild-typemice. A 13.5-fold increase in loperamide concentration wasfound in the brain of the knockouts. In addition, the micelacking the P-glycoprotein pump displayed pronouncedsigns of central opiate agonism. Loperamide is availableas 2-mg capsules for treatment of acute and chronic diarrhea.Recommended dosage is 4 mg initially, with 2 mgafter each loose stool for a maximum of 16 mg/d.

• Company Name:Finetech Industry Limited
• Tel:027-87465837 19945049750
• Products Intro:Product Name:Loperamide
  CAS:53179-11-6
  Purity:98% Package:1g;10g;25g;500g;1kg
• CB Index:58
• Related Information:Catalog(9648)

• Company Name:Amadis Chemical Company Limited
• Tel:571-89925085
• Products Intro:Product Name:4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-N,N-dimethyl-2,2-diphenylbutanamide
  CAS:53179-11-6
  Purity:0.97 Package:mgs,gs,kgs Remarks:A829430
• CB Index:58
• Related Information:Catalog(131957)

• Company Name:Zeshan Cheng New Materials (Wuhan) Co., Ltd
• Tel:027-51477051 17786425391
• Products Intro:Product Name:Loperamide
  CAS:53179-11-6
  Purity:99% HPLC Package:25KG
• CB Index:58
• Related Information:Catalog(369)