Cenicriviroc
497223-25-3 Basic informationMore
- Product Name:Cenicriviroc
- Synonyms: Cenicriviroc TAK652 Cenicriviroc mesylate (TAK-652) Cenicriviroc(TAK652) TAK-652; TAK652; TAK 652; TBR-652; TBR 652; TBR652; CENICRIVIROC. CS-2572 TAK-652; TBR-652; TAK652; TBR652; TAK 652; TBR 652 TBR 652
- CAS:497223-25-3
- MF:C41H52N4O4S
- MW:696.94
- EINECS:
- Mol File:497223-25-3.mol
-
USE
Cenicriviroc is a dual antagonist of chemokine receptor types 2 and 5 (CCR2/CCR5). The receptors are found on Kupffer cells and hepatic stellate cells, and preclinical studies suggest its anti-inflammatory and anti-fibrotic activity. In the phase 2b CENTAUR study, cenicriviroc treatment for 1 year failed to achieve the primary outcome of a decrease in NAFLD activity score by ≥2 points with no worsening of fibrosis. Nonetheless, one of the key secondary outcomes, improvement in liver fibrosis without worsening of NASH, was achieved in 20% in the treatment group, compared with 10% in the placebo group. Besides, cenicriviroc reduced the serum levels interleukin- 6, C-reactive protein and fibrinogen, suggesting its action on inflammation that may not be reflected by crude histological assessment. A phase 3 study is planned.
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Cenicriviroc
CAS:497223-25-3
Package:10Mg,1Mg More... - CB Index:76
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- Company Name:ChengDu TongChuangYuan Pharmaceutical Co.Ltd
- Tel:28-83379370 13880556291
- Products Intro:Product Name:cenicriviroc
CAS:497223-25-3
Purity:99% HPLC Package:5KG;1KG - CB Index:57
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- Company Name:WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
- Tel:17702719238 17702719238
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CAS:497223-25-3
Purity:98% HPLC Package:50.0mg;100.0mg; 200.0mg;500mg;1g;5g; 10g More... - CB Index:64
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- Company Name:QINGDAO CARELONGPHARMATECH CO.,LTD
- Tel:0532-0532-88191853 13061484198
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Purity:95%+ Package:500MG/;1g/;5g/ - CB Index:57
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- Company Name:ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel:18149758185 18149758185
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CAS:497223-25-3
Purity:98% Package:10mg;100mg;1g;10g;100g;1kg - CB Index:58
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- Company Name:Cool Pharm, Ltd
- Tel:021-58581007 18019463053
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Purity:95.0% Package:10g;25g;100g;500g;1kg;5kg;10kg - CB Index:58
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- Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
- Tel:021-52996696，15000506266 15000506266
- Products Intro:Product Name:TAK652
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Purity:>98% Package:2g Remarks:2g More... - CB Index:55
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