Tegaserod maleate
189188-57-6 Basic informationMore
- Product Name:Tegaserod maleate
- Synonyms: SDZ-HTF-919 TEGASEROD MALEATE ZELMAC 2-[(5-METHOXY-1H-INDOL-3-YL)METHYLENE]-N-PENTYLHYDRAZINECARBOXIMIDAMIDE, MALEATE 2-[(5-methoxy-1h-indole-3-yl)methylene]-n-pentylcarbazimidamide hydrogen maleate TegaserodMalate TegastrodMaleate SDZ-HTF-919, Zelmac, 2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide, Maleate
- CAS:189188-57-6
- MF:C20H27N5O5
- MW:417.46
- EINECS:630-469-2
- Mol File:189188-57-6.mol
-
USE
Tegaserod maleate was launched as a new oral treatment of constipationpredominant
or diarrhea-predominant irritable bowel syndrome. It can be prepared by
condensation of the 5-methoxy-3-formylindole with the appropriate aminoguanidine.
Tegaserod is a selective partial agonist of the excitatory 5-HT<sub>4</sub> receptor (K<sub>1</sub> = 18 nM in
human caudate membranes) and was designed from the endogenous full agonist,
seretonin. In the model of potentiation of the electrically stimulated contraction of
longitudinal muscle of guinea pig ileum, Tegaserod exhibited a low-efficacy agonistic
activity compared with serotonin. However, it appeared more potent in several studies on
intestinal mucosal tissue from various species including man. A lack of effect on the QTc
interval was shown in rabbits then confirmed during clinical studies. Tegaserod is also
clinically developed for the treatment of other functional GI disorders such as functional
dyspepsia and gastroesophageal reflux disease (GERD).
Lastest Price from Tegaserod maleate manufacturers
- Tegaserod maleate
-
- US $10.00 /kg
- CAS:189188-57-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000tons
- 2023-09-07
- Tegaserod maleate
-
- US $88.00 /KG
- CAS:189188-57-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1 ton
- 2022-09-01
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Tegaserod Maleate
CAS:189188-57-6
Package:100Mg,10Mg More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:Tegaserod Maleate
CAS:189188-57-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15839)
- Company Name:XiaoGan ShenYuan ChemPharm co,ltd
- Tel: 15527768850
- Products Intro:Product Name:NA
More... - CB Index:52
- Related Information:Catalog(8843)