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Mizolastine

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108612-45-9 Basic informationMore
USE
Mizolastine was marketed in Germany and Switzerland as Mizollen for the symptomatic relief of seasonal and perennial allergic rhinoconjunctivitis and urticaria. Mizolastine is a new long-acting, orally active antihistaminic agent with a rapid onset of action ; the two most recent H1 antagonists launched were fexofenadine, metabolite of terfenadine (Sepracor, 1996) and Olopatadine (Kyowa Hakko, 1997). Mizolastine can be prepared in 2 steps from 2-chloro 1- (4-fluorobenzyl)benzimidazole by successive condensations of appropriate amine and thioether. Mizolastine selectively blocks the peripheral H1 receptors (but not the serotonergic, noradrenergic, muscarinic receptors) with a minimal occupancy of brain receptors, and therefore does not elicit any sedative effects. Moreover, Mizolastine does not produce cardiac rhythm disorders which have been associated with certain non-sedating antihistamines in humans.
Lastest Price from Mizolastine manufacturers
  • Mizolastine
  • US $0.00 /kg
  • CAS:108612-45-9
  • Min. Order: 1kg
  • Purity: 98.0 ~ 102%
  • Supply Ability: 20tons
  • 2024-10-25
  • Mizolastine
  • US $100.00 /kg
  • CAS:108612-45-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 1000tons
  • 2023-09-07

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