Vildagliptin

• Product Name:Vildagliptin
• Synonyms: Vidagliptin (see vildagliptin) Vildagliptin 1-[2-(3-HydroxyadaMant-1-ylaMino)acetyl]pyrrolidine-2(S)-carbonitrile (S)-1-[2-((5S,7S)-3-hydroxy-adaMantan-1-ylaMino)-acetyl]-pyrrolidine-2-carbonitrile NVP-LAF 237 ZoMelis Vildagliptin API Vildagliptin (NVP-LAF 237)
• CAS:274901-16-5
• MF:C17H25N3O2
• MW:303.4
• EINECS:630-410-0
• Mol File:274901-16-5.mol
• 

Vildagliptin, a DPP-4 inhibitor, was launched for the oral treatment of type 2 diabetes. Vildagliptin is the second DPP-4 inhibitor to reach the market behind sitagliptin, which was introduced in 2006. DPP-4 inhibitors act by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase the synthesis and release of insulin from pancreatic βcells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic α cells, which leads to reduced hepatic glucose production. However, although GLP-1 and GIP effectively lower blood glucose, they are short-lived as a result of rapid inactivation by the ubiquitous serine protease DPP-4. By inhibiting DPP-4, vildagliptin increases the concentration and duration of active incretin levels, which in turn results in increased insulin release and decreased glucagon levels in a glucose-dependent manner. Both vildagliptin and sitagliptin are potent, competitive, reversible inhibitors of DPP- 4 (IC₅₀=3.5 and 18 nM, respectively), and they both show slow, tight-binding inhibition kinetics.

• Vildagliptin
• 
• US $0.00-0.00/g
• CAS:274901-16-5
• Min. Order: 1g
• Purity: 99% HPLC
• Supply Ability: 10000
• 2024-12-24

• Vildagliptin
• 
• US $0.00 /g
• CAS:274901-16-5
• Min. Order: 1g
• Purity: More Than 99%
• Supply Ability: 100kg/Month
• 2024-12-23

• Company Name:AnHui HaiKang Pharmaceutical Co., Ltd.
• Tel:0556-5800026 17709662922
• Products Intro:Product Name:Vildagliptin
  CAS:274901-16-5
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• Company Name:Viwit Pharmaceutical Co., Ltd.
• Tel:0632-0632-2980981 15063270987
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  CAS:274901-16-5
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• Company Name:TIANJIN MINXIANG BIOMEDICAL INC.
• Tel:022-59596766 13313219033 18222332696
• Products Intro:Product Name:Vildagliptin
  CAS:274901-16-5
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• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Vildagliptin, 97%, DPP-4 inhibitor
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• Company Name:Chemvon Biotechnology Co., Ltd
• Tel:021-50790412
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• Company Name:Chembest Research Laboratories Limited
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• Company Name:Beijing HwrkChemical Technology Co., Ltd
• Tel:010-89508211 18501085097
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  CAS:274901-16-5
  Purity:99%,单杂0.1% Package:100g
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