Azlocillin
37091-66-0 Basic informationMore
- Product Name:Azlocillin
- Synonyms: AZLOCILLIN ACID 3,3-Dimethyl-6-oxo-7-[2-(2-oxoimidazolidin-1-yl)carbonylamino-2-phenyl-acetyl]amino-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylic acid 3,3-Dimethyl-7-oxo-6-[[[[(2-oxoimidazolidin-1-yl)carbonyl]amino]phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Azlocillin [2S-[2a,5a,6(s*)]]3,3-dimethyl-7-oxo-6{[[[[(2-oxoimideazolidine-1-yl)carbonyl]amino]phenylacethyl]-amino]-4-thia-1-azabicyclo[3,2,0]-heptane-2-carboxylic acid 6α-[[(R)-[[(2-Oxo-1-imidazolidinyl)carbonyl]amino]phenylacetyl]amino]penicillanic acid Azlocillin solution,100ppm (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[(2S)-1-oxo-2-[[oxo-(2-oxo-1-imidazolidinyl)methyl]amino]-2-phenylethyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- CAS:37091-66-0
- MF:C20H23N5O6S
- MW:461.49
- EINECS:2533482
- Mol File:37091-66-0.mol
-
USE
A semisynthetic acylureidopenicillin supplied as the sodium
salt for parenteral administration. It is active against a wide
range of other Gram-negative bacteria, but is distinguished
mainly by its activity against Ps. aeruginosa. B.
fragilis and other anaerobes are moderately susceptible. Like
other ureidopenicillins, azlocillin is active against Grampositive
cocci, H. influenzae and N. gonorrhoeae. Because it can
be hydrolyzed by most β-lactamases, β-lactamase-producing
isolates are resistant.<br/>
It attains peak concentrations of 250 mg/L after a 3 g intravenous
infusion, with a plasma half-life of approximately 1 h.
Protein binding is 20–30%. It distributes into multiple tissues
and human body fluids at therapeutically useful concentrations.
Up to 60% of the dose is recoverable from the urine,
mostly unchanged, although some hydrolysis of the β-lactam
ring takes place in the body.<br/>
Toxicity and side effects are similar to those associated
with carboxypenicillins. Its clinical use is for serious infections
with susceptible organisms, including lower respiratory tract,
intra-abdominal, urinary tract and gynecological infections.
Commercial availability is quite limited.
Lastest Price from Azlocillin manufacturers
- Azlocillin
-
- US $0.00 /KG
- CAS:37091-66-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
- 2024-11-04
- Azlocillin
-
- US $0.00 /KG
- CAS:37091-66-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- 2023-11-13
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- Company Name:XiaoGan ShenYuan ChemPharm co,ltd
- Tel: 15527768850
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