Bexarotene
153559-49-0 Basic informationMore
- Product Name:Bexarotene
- Synonyms: LG 69 RO 26-4455 Targret Bexarotene(4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)ethenyl]benzoic acid Bexarotene, Free Bexarotenecas Bexarotene (Targretin Targrexin) Bexarotene(LGD-1069)
- CAS:153559-49-0
- MF:C24H28O2
- MW:348.48
- EINECS:
- Mol File:153559-49-0.mol
-
USE
Bexarotene was launched in the US for the treatment of manifestations of cutaneous T-cell
lymphoma in patients who are refractory to at least one prior systemic therapy. The
four step synthesis of bexarotene involves a double Friedel-Craft alkylation of toluene with
2,5-dichloro-2,5-dimethylhexane followed by acylation with monomethylterephthalic acid
chloride, then Wittig methylidenation. Bexarotene is the first retinoid X receptor (RXR)
agonist to be selective versus retinoid A receptors (RAR). Its activation of the three
RXRα, β, γ isoforms induces cell differentiation and apoptosis and inhibits cell proliferation
in several models of cancer. In phase ll/lll clinical trials, 48% of patients with refractory or
persistent early-stage cutaneous T-cell lymphoma achieved a complete or partial response
when treated with 300 mg/m2/day of bexarotene. It was shown in phase I trials that this
second-generation retinoid was substantially less toxic than the broad-spectrum or RARselective
retinoids.
Lastest Price from Bexarotene manufacturers
- Bexarotene
-
- US $1.00 /KG
- CAS:153559-49-0
- Min. Order: 1KG
- Purity: 99.91%
- Supply Ability: 200000
- 2024-04-22
- Bexarotene
-
- US $0.00-0.00/KG
- CAS:153559-49-0
- Min. Order: 5mg
- Purity: 99%
- Supply Ability: 2000tons
- 2024-02-01
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- Company Name:Chembest Research Laboratories Limited
- Tel:021-20908456
- Products Intro:Product Name:Bexarotene(LGD-1069)
CAS:153559-49-0
Purity:99% Package:10g Remarks:C13375 More... - CB Index:61
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- Tel:010-82848833 400-666-7788
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Purity:99% Package:100mg;10mg;50MG More... - CB Index:76
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Purity:96.0% LC Package:100MG More... - CB Index:81
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- Tel:400-6009262 16621234537
- Products Intro:Product Name:4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Vinyl)Benzoic Acid
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Purity:98% Package:100mg;250mg;1g;5g;25g - CB Index:59
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- Tel:021-58099652-8005 13585536065
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Purity:99% More... - CB Index:59
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- Company Name:Nanjing Chemlin Chemical Co., Ltd
- Tel:025-83697070
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Purity:98% Package:5KG;1KG More... - CB Index:64
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- Company Name:Shanghai Hanhong Scientific Co.,Ltd.
- Tel:021-54306202 13764082696;
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CAS:153559-49-0
Purity:98+% Remarks:GN0100514 More... - CB Index:64
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