Bexarotene
153559-49-0 Basic informationMore
- Product Name:Bexarotene
- Synonyms: LG 69 RO 26-4455 Targret Bexarotene(4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)ethenyl]benzoic acid Bexarotene, Free Bexarotenecas Bexarotene (Targretin Targrexin) Bexarotene(LGD-1069)
- CAS:153559-49-0
- MF:C24H28O2
- MW:348.48
- EINECS:
- Mol File:153559-49-0.mol
-
USE
Bexarotene was launched in the US for the treatment of manifestations of cutaneous T-cell
lymphoma in patients who are refractory to at least one prior systemic therapy. The
four step synthesis of bexarotene involves a double Friedel-Craft alkylation of toluene with
2,5-dichloro-2,5-dimethylhexane followed by acylation with monomethylterephthalic acid
chloride, then Wittig methylidenation. Bexarotene is the first retinoid X receptor (RXR)
agonist to be selective versus retinoid A receptors (RAR). Its activation of the three
RXRα, β, γ isoforms induces cell differentiation and apoptosis and inhibits cell proliferation
in several models of cancer. In phase ll/lll clinical trials, 48% of patients with refractory or
persistent early-stage cutaneous T-cell lymphoma achieved a complete or partial response
when treated with 300 mg/m2/day of bexarotene. It was shown in phase I trials that this
second-generation retinoid was substantially less toxic than the broad-spectrum or RARselective
retinoids.
Lastest Price from Bexarotene manufacturers
- Bexarotene
-
- US $0.00-0.00/KG
- CAS:153559-49-0
- Min. Order: 5mg
- Purity: 99%
- Supply Ability: 2000tons
- 2025-01-03
- Bexarotene
-
- US $10.00 /KG
- CAS:153559-49-0
- Min. Order: 100KG
- Purity: 99%
- Supply Ability: 100 mt
- 2024-12-02
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- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:Bexarotene(LGD-1069)
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Purity:99% Package:10g Remarks:C13375 More... - CB Index:61
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