CHIR-090
728865-23-4 Basic informationMore
- Product Name:CHIR-090
- Synonyms: CHIR-090 N-[(1S,2R)-2-Hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[[4-(4-morpholinylmethyl)phenyl]ethynyl]benzamide N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]benzamide CHIR-090 (CHIR 090 CS-2285 Benzamide, N-[(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]- N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morphChemicalbookolin-4-ylmethyl)phenyl]ethynyl]benzamide N-((2S,3R)-3-Hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide
- CAS:728865-23-4
- MF:C24H27N3O5
- MW:437.49
- EINECS:
- Mol File:728865-23-4.mol
-
USE
CHIR-090 is the first reported compound that in fact kills both E. coli and Pseudomonas aeruginosa in bacterial disk diffusion assays (Liang et al. 2011). Nonetheless, CHIR-090 was about 600-fold less effective against LpxC orthologs from the Rhizobiaceae family than against E. coli LpxC. In this way, studies have shown that the removal of morpholine ring, based on a chemical scaffold of reduced radius, was able to increase affinity by 20-fold for LpxC enzymes from the Rhizobiaceae family of bacteria and enhance the antibiotic activity against E. coli and P. aeruginosa by 2–4 fold over CHIR-090.
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- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel:400-400-6206333 18521732826
- Products Intro:Product Name:CHIR-090
CAS:728865-23-4
Purity:>=98% Package:10mg/RMB 2389.90;50mg/RMB 9197.90;5mg/RMB 1301.90 More... - CB Index:65
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- Company Name:TargetMol Chemicals Inc.
- Tel:021-021-33632979 15002134094
- Products Intro:CAS:728865-23-4
Package:1 mL;10 mg;2 mg;25 mg;5 mg;50 mg More... - CB Index:58
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- Company Name:AdooQ Bioscience CHINA
- Tel:025-58849295 18951903616;
- Products Intro:Product Name:CHIR-090
CAS:728865-23-4
Purity:0.98 Package:1mg;5mg;10mg;25mg;50mg;100mg More... - CB Index:60
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- Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
- Tel:021-52996696，15000506266 15000506266
- Products Intro:Product Name:chir-090
CAS:728865-23-4
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G More... - CB Index:55
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- Company Name:Shanghaizehan biopharma technology co., Ltd.
- Tel:021-61350663 13052117465
- Products Intro:Product Name:CHIR-090
CAS:728865-23-4
Purity:98% Package:1g/;5g/ - CB Index:55
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