GSK1349572

• Product Name:GSK1349572
• Synonyms: Dolutegravir API 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)- (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide Dolutegravir (GSK1349572) GSK1349572, S-349572, GSK572 (4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide Dolutegravir, >=98% Dolutegravir free acid GSK1349572
• CAS:1051375-16-6
• MF:C20H19F2N3O5
• MW:419.38
• EINECS:
• Mol File:1051375-16-6.mol
• 

In August 2013, the US FDA approved dolutegravir (also referred to as S/GSK1349572) for the treatment of HIV-1 infection in adults and children ages 12 years and older in combination with other antiretroviral drugs. Dolutegravir was approved in Canada in November 2013. HIV/AIDS remains a global epidemic with 35 million people infected, including 2.3 million new infections as of 2012. Dolutegravir joins raltegravir and elvitegravir (this chapter of ARMC) as the latest of three FDA-approved HIV integrase strand transfer inhibitors (INSTIs). Dolutegravir was discovered by rational design from a literature diketo acid HIV integrase inhibitor utilizing X-ray coordinates to predict ideal bond angles between the diketone and distal benzyl group. In dolutegravir, the monocyclic component of the reported inhibitor was replaced with the tricyclic carbamoyl pyridone moiety. The researchers postulated that the appropriate arrangement of three oxygens would permit chelation with two magnesium ions in the binding site thus affording improved potency. Ultimately, this arrangement along with further modifications afforded dolutegravir, a potent inhibitor of HIV integrase (IC₅₀=1.7 nM).

• Dolutegravir
• 
• US $120.00-80.00/g
• CAS:1051375-16-6
• Min. Order: 1g
• Purity: 98%HPLC
• Supply Ability: 1T
• 2024-01-04

• Dolutegravir; DTG; GSK1349572
• 
• US $240.00 /g
• CAS:1051375-16-6
• Min. Order: 10g
• Purity: 99% Purity (What/sapp: +86 18145728414)
• Supply Ability: 1000 Tons/Month
• 2023-11-16

• Company Name:Suzhou Laihui Biotechnology Co., Ltd.
• Tel:180-13160973 +86-18013160973
• Products Intro:Product Name:GSK1349572
  CAS:1051375-16-6
  Purity:99% Package:5KG/ More...
• CB Index:55
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• Company Name:ShangHai Biochempartner Co.,Ltd
• Tel:17754423994 17754423994
• Products Intro:Product Name:Dolutegravir
  CAS:1051375-16-6
  Purity:98% HPLC LCMS Package:100mg/RMB 99 More...
• CB Index:62
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• Company Name:Bono Kangyuan (Beijing) Pharmaceutical Technology Co., Ltd
• Tel:010-56380788-8515 16619769925
• Products Intro:Product Name:(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
  CAS:1051375-16-6
  Purity:99% HPLC Package:500g；1kg（可根据客户要求包装）
• CB Index:58
• Related Information:Catalog(53)

• Company Name:Hubei Kele Fine Chemical Co., Ltd
• Tel:027-59101668 19945030958
• Products Intro:Product Name:GSK1349572
  CAS:1051375-16-6
  Purity:98% HPLC Package:1g;100g;1kg
• CB Index:58
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• Company Name:Wuhan Augda Biotechnology Co., Ltd
• Tel: 15071299552
• Products Intro:Product Name:GSK1349572
  CAS:1051375-16-6
  Purity:98% Package:mg；g；kg
• CB Index:58
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• Company Name:Changzhou Yongfeng Biomedicine Co. Ltd.
• Tel: 15006117673
• Products Intro:Product Name:Dolutegravir,GSK1349572
  CAS:1051375-16-6
  Package:10g/
• CB Index:58
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• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Dolutegravir
  CAS:1051375-16-6
  Package:10Mg,2.5Mg,50Mg,5Mg More...
• CB Index:76
• Related Information:Catalog(94838)