Alteplase
105857-23-6 Basic informationMore
- Product Name:Alteplase
- Synonyms: Alteplase Activase (tn) Alteplase (genetical recombination) Alteplase (genetical recombination) (jan) Alteplase (usp/inn) D02837 PlasMinogen activator (huMan tissue-type protein Moiety) (9CI) Alteplase USP/EP/BP
- CAS:105857-23-6
- MF:
- MW:0
- EINECS:
- Mol File:Mol File
-
USE
Alteplase (Activase) is a tissue plasminogenactivator (t-PA) produced by rDNA technology. It is a single-chain glycoprotein protease consisting of 527 aminoacid residues. Native t-PA is isolated from a melanoma cellline. The single-chain molecule is susceptible to enzymaticdigestion to a two-chain molecule, in which the two chainsremain linked with a disulfide bond. Both forms of the nativet-PA are equipotent in fibrinolytic (and plasminogenactivating)properties. It is an extrinsic plasminogen activatorassociated with vascular endothelial tissue, whichpreferentially activates plasminogen bound to fibrin. Thefibrinolytic action of alteplase (t-PA) is confined to thrombi,with minimal systemic activation of plasminogen. It is producedcommercially by rDNA methods by inserting the alteplasegene (acquired from human melanoma cells) intoovarian cells of the Chinese hamster, serving as host cells.The melanoma-derived alteplase is immunologically andchemically identical with the uterine form. Alteplase is indicatedfor the intravenous management of acute myocardialinfarction.
Browse by Nationality 105857-23-6 Suppliers >Global suppliers
Beijing (1) Shanghai (1) Guangdong (1) Zhejiang (3) Hubei (2) Shandong (1) Henan (2) Anhui (1) Shaanxi (1) Member (13) All (13)
Please select the suppliers
Recommend You Select Member Companies
Recommend You Select Member Companies
- Company Name:AFINE CHEMICALS LIMITED
- Tel:+86-0571-85134551
- Products Intro:Product Name:ALTEPLASE
CAS:105857-23-6
Purity:98%+ Package:Standard or custom package Remarks:excellent quality and reliable supplier - CB Index:58
- Related Information:Catalog(15372)
- Company Name:Dideu Industries Group Limited
- Tel:+86-29-89586680 +86-15129568250
- Products Intro:Product Name:Alteplase
CAS:105857-23-6
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer - CB Index:58
- Related Information:Catalog(23498)
- Company Name:Shanghai Jiegu Biotechnology Co., Ltd.
- Tel:021-51698675
- Products Intro:Product Name:Alteplase
CAS:105857-23-6
Purity:97% HPLC Package:100KG;1KG - CB Index:58
- Related Information:Catalog(4249)
- Company Name:Hubei Qifei Pharmaceutical Chemical Co., Ltd
- Tel:027-027-59322506 18071128681
- Products Intro:CAS:105857-23-6
Purity:99% HPLC Package:25KG;200KG;5KG;1KG;1T - CB Index:58
- Related Information:Catalog(9978)