Ramatroban

• Product Name:Ramatroban
• Synonyms: BAY-U3405 3R-[[(4-FLUOROPHENYL)SULFONYL]AMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-PROPANOIC ACID (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propionic acid 3-[(3R)-3-(4-Fluorophenylsulfonylamino)-1,2,3,4-tetrahydro-9H-carbazole-9-yl]propionic acid (R)-3-(3-(4-fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)propanoic acid RAFFINOSE UNDECAACETATE, D-(+)-(RG) (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoicacid RaMatroban(BAY-u3405)
• CAS:116649-85-5
• MF:C21H21FN2O4S
• MW:416.47
• EINECS:
• Mol File:116649-85-5.mol
• 

Ramatroban, originally developed for the treatment of cardiovascular pathologies as thromboembolism, was finally introduced in Japan for the treatment of allergic rhinitis. It is a (3R)-enantiomer that can be synthesized in 5 steps from 3-oxo-1,2,3,4- tetrahydrocarbazole by stereoselective reductive amination, using S-phenethylamine as the chiral source, followed by hydrogenolysis, sulfonylation and finally 2-step Ncarboxyethylation. Ramatroban is a potent antagonist of prostaglandin receptors (PGD₂, PGH₂) and thromboxane receptors (TxA₂); accordingly, it blocks the contractions induced by thromboxane or TxA₂-mimetics in animal and human airway smooth muscle. It also prevents, when administered i.v., p.o. or by aerosol, bronchoconstriction induced by PGD₂ or antigen. In animal models of nasal allergy, ramatroban inhibits antigen-induced neutrophil infiltration into nasal mucosa and also inhibits nasal symptoms. In several species including humans, it is well-absorbed, extensively protein-bound (>95%) and eliminated mainly as a glucuro-conjugate; in man, its terminal half-life is 2 to 3 hours.

• Ramatroban
• 
• US $0.00 /g
• CAS:116649-85-5
• Min. Order: 1g
• Purity: More Than 99%
• Supply Ability: 100kg/Month
• 2024-11-18

• Ramatroban
• 
• US $300.00 /g
• CAS:116649-85-5
• Min. Order: 1g
• Purity: 98%
• Supply Ability: 100TONS
• 2022-06-06

• Company Name:Wuhan Augda Biotechnology Co., Ltd
• Tel: 15071299552
• Products Intro:Product Name:Ramatroban
  CAS:116649-85-5
  Purity:98% Package:mg；g；kg
• CB Index:58
• Related Information:Catalog(6883)

• Company Name:Heze Development Zone chuangli Chemical Co., Ltd.
• Tel:+86-530-529 6766，+86-15666160102 15666160102
• Products Intro:Product Name:Ramatroban
  CAS:116649-85-5
  Purity:98% HPLC Package:500mg,1g,5g,10g,50g,100g More...
• CB Index:55
• Related Information:Catalog(894)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:RaMatroban
  CAS:116649-85-5
  Package:100Mg,10Mg More...
• CB Index:76
• Related Information:Catalog(94657)

• Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
• Tel:821-50328103-801 18930552037
• Products Intro:Product Name:BAY-u 3405;(3R)-3-[[(4-Fluorophenyl)sulfonyl]aMino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoicacid
  CAS:116649-85-5
  Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
• CB Index:69
• Related Information:Catalog(15839)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:Ramatroban
  CAS:116649-85-5
  Purity:98% Package:10mg;50mg;100mg;500mg;1g;5g;10g;50g;100g Remarks:C14084 More...
• CB Index:61
• Related Information:Catalog(6005)