GSK 343
1346704-33-3 Basic informationMore
- Product Name:GSK 343
- Synonyms: 1H-Indazole-4-carboxamide, N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]- 1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide GSK343 GSK 343 GSK343 GSK-343 GSK-343/GSK343 1-(1-Methylethyl)-N-[(6-Methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)Methyl]-6-[2-(4-Methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxaMide N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-py
- CAS:1346704-33-3
- MF:C31H39N7O2
- MW:541.69
- EINECS:
- Mol File:1346704-33-3.mol
-
USE
GSK343 inhibits trimethylation of H3K27 (H3K27me3) with IC50 of 174 nM in HCC1806 breast cancer cells. GSK343 potently inhibits cell proliferation in breast cancer cells and prostate cancer cells, and the prostate cancer cell line LNCaP is the most sensitive to GSK343, with IC50 of 2.9 μM. GSK343 significantly suppresses the growth of EOC cells cultured in 3D matrigel extracellular matrix (ECM), which mimics the tumor microenvironment in vivo. In addition, GSK343 also induces apoptosis of EOC cells in 3D and significantly inhibits the invasion of EOC cells.
Lastest Price from GSK 343 manufacturers
Browse by Nationality 1346704-33-3 Suppliers >Global suppliers
Beijing (9) Shanghai (46) Sichuan (2) Guangdong (10) Zhejiang (4) Hunan (1) Hubei (16) Shandong (4) Henan (6) Jilin (5) Liaoning (1) Anhui (2) Jiangsu (14) Shaanxi (2) Member (122) All (122)
Please select the suppliers
Recommend You Select Member Companies
Recommend You Select Member Companies
- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:1-(1-Methylethyl)-N-[(6-Methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)Methyl]-6-[2-(4-Methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxaMide
CAS:1346704-33-3
Package:25Mg,5Mg More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:ChemCell Biomedicine Co.,Ltd.
- Tel:020-13556033878 2965585218 13556033878
- Products Intro:Product Name:gsk343
CAS:1346704-33-3
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；250mg；500mg；1g；5g；10g；25g；100g - CB Index:52
- Related Information:Catalog(369)
- Company Name:Wuhan Fortuna Chemical Co., Ltd
- Tel:027-59207852 13308628970
- Products Intro:Product Name:GSK 343
CAS:1346704-33-3
Purity:99% Package:1kg More... - CB Index:58
- Related Information:Catalog(2871)
- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:GSK-343
CAS:1346704-33-3
Purity:>98%,BR Package:5MG;25MG; Remarks:MB3793 - CB Index:58
- Related Information:Catalog(4727)