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Aflibercept

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In November 2011, the U.S. FDA approved the recombinant fusion protein aflibercept, administered as an intravitreal injection, for the treatment of patients with neovascular (wet) age-related macular degeneration (AMD). Aflibercept differs from these agents in that it acts as a soluble decoy receptor that binds all VEGF isoforms more tightly than their native receptors, thereby diverting VEGF from its normal function. Aflibercept consists of a fusion of the second Ig domain of human VEGF receptor 1 and the third Ig domain of human VEGF receptor 2 fused to the constant region of (Fc) of human immunoglobulin G1. Aflibercept is a dimeric glycoprotein with a protein molecular weight of 97 kDa and glycoside molecular weight of 18 kDa. It is produced in recombinant Chinese hamster ovary (CHO) cells that overexpress the fusion protein. Aflibercept has subpicomolar affinity for VEGF-A (K<sub>D</sub>=0.66 pM for VEGF-A<sub>165</sub> and 0.19 pM for VEGF-A<sub>121</sub>), the major driver of pathological angiogenesis and vascular leak in wet AMD.19 Ranibizumab and bevacizumab bind VEGF-A<sub>165</sub> with lower affinity (K<sub>D</sub>=20.6 and 35.1 pM, respectively).

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  • Company Name:Chembest Research Laboratories Limited
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  • Company Name:Shanghai EFE Biological Technology Co., Ltd.
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  • Company Name:Shanghai Rechem science Co., Ltd.
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  • Company Name:AFINE CHEMICALS LIMITED
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    Purity:98%+ Package:Standard or custom package Remarks:excellent quality and reliable supplier
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  • Company Name:DC Chemicals
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  • Company Name:Wuhan Chemstan Biotechnology Co., Ltd.
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    Purity:98% Package:100mg
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