Modafinil
68693-11-8 Basic informationMore
- Product Name:Modafinil
- Synonyms: MODAFINIL Acetamide, 2-[(diphenylmethyl)sulfinyl]- Modiodal (Benzhydrylsulfinyl)acetamide Modafinilrac 2-[di(phenyl)methylsulfinyl]ethanamide Modafinil,2-[(Diphenylmethyl)sulfinyl]-acetamide Modafinil CIV (200 mg)F0D3510.997mg/mg(ai)
- CAS:68693-11-8
- MF:C15H15NO2S
- MW:273.35
- EINECS:640-968-7
- Mol File:68693-11-8.mol
USE
Modafinil, a centrally active α<sub>1</sub>-adrenergic agonist, was marketed in France as a
psychostimulant for the treatment of narcolepsy and idiopathic hypersomnia
including Gelineau's syndrome. In monkeys, modafinil was found to induce potent
behavioral stimulation and awakening without stereotyped behavior. In narcoleptic
patients, modafinil reduces the daily number of sleep attacks significantly and
markedly improves performance. The mechanism of action for its locomotor effects
was reported to be due to the stimulation of the central α<sub>1</sub>-adrenergic system,
opposite to amphetamine and methylphenidate, which act mainly by dopaminergic
mechanisms. Modafinil has been reported to exhibit minimal peripheral side effects
at therapeutic doses and appears to have low abuse potential. The use of modafinil
in the treatment of cerebral infarction and ischemia has been claimed.
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