Lomerizine hydrochloride

• Product Name:Lomerizine hydrochloride
• Synonyms: 1-(4,4'-Difluorobenzhydryl)-4-(2,3,4-trimethoxybenzyl)piperazine·dihydrochloride Flometizine hydrochloride Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2) Lomerizine dihydrochloride, >=99% 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride 1-(2,3,4-trimethoxybenzyl)-4-(bis(4-fluorophenyl)methyl)piperazinedihydrochl 1-(bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)-piperazin 1-(bis(4-fluorophenyl)methyl)-4-((2,3,4-trimethoxyphenyl)methyl)piperazined
• CAS:101477-54-7
• MF:C27H32Cl2F2N2O3
• MW:541.46
• EINECS:
• Mol File:101477-54-7.mol
• 

Lomerizine hydrochloride was introduced as Teranas and Migsis in Japan for the treatment of migraine. It is the first in its class of dual sodium and calcium channel blockers to be marketed for this indication. It can be synthetically obtained by reductive amination of 2,3,4-trimethoxybenzaldehyde with the appropiate benzhydryl piperazine. In dogs, Lomerizine exerts a potent, selective and long-lasting vasodilation of cerebral arteries related to a combination of mechanisms, especially a functional block of L-type voltagesensitive calcium channels (L-VSCCs). Lomerizine increases cerebral blood flow compared to peripheral blood flow with only weak effects on systemic arterial blood pressure. Other mechanisms involved could be blockade of other VSCC and sodium channels, 5-HT2 and alpha-1 receptors. As a reducing agent of cortical spreading depression and neurogenic inflammation, Lomerizine was shown to be useful in migraine. In an open clinical study, it demonstrated efficacy in the treatment of cluster headache. Moreover, it may have utility in other neurological diseases such as cerebrovascular ischemia or cerebral infarction.

• Company Name:Shandong Chenlong Pharmaceutical Co., Ltd.
• Tel:0537-6460896
• Products Intro:Product Name:Lomerizine hydrochloride
  CAS:101477-54-7
  
• CB Index:58
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• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Lomerizine dihydrochloride, 99%, a new L- and T-type calcium channel blocker
  CAS:101477-54-7
  Purity:99% Package:1G;5G More...
• CB Index:76
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• Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
• Tel:821-50328103-801 18930552037
• Products Intro:Product Name:LoMerizine hydrochloride
  CAS:101477-54-7
  Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
• CB Index:69
• Related Information:Catalog(15839)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:LoMerizine Hydrochloride
  CAS:101477-54-7
  Remarks:C14893 More...
• CB Index:61
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• Company Name:TCI (Shanghai) Development Co., Ltd.
• Tel:021-67121386
• Products Intro:Product Name:Lomerizine Dihydrochloride
  CAS:101477-54-7
  Purity:98.0% LC&T Package:1G,200MG More...
• CB Index:81
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• Company Name:XiaoGan ShenYuan ChemPharm co,ltd
• Tel: 15527768850
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• CB Index:52
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• Company Name:Shandong Xiya Chemical Co., Ltd
• Tel:4009903999 13355009207
• Products Intro:CAS:101477-54-7
  Purity:>=98.0% Package:200mg
• CB Index:57
• Related Information:Catalog(18738)