Eflornithine
67037-37-0 Basic informationMore
- Product Name:Eflornithine
- Synonyms: D,L-2-DIFLUOROMETHYLORNITHINE H-DL-(A-DIFLUOROMETHYL)ORN-OH Eflornithine base Ornidyl Eflornithine 2-(Difluoromethyl)ornithine 2,5-bis(azanyl)-2-(difluoromethyl)pentanoic acid 2,5-diamino-2-(difluoromethyl)valeric acid
- CAS:67037-37-0
- MF:C6H12F2N2O2
- MW:182.17
- EINECS:
- Mol File:67037-37-0.mol
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USE
Eflornithine is used for the treatment of West African sleepingsickness, caused by Trypanosoma brucei gambiense.It is specifically indicated for the meningoencephaliticstage of the disease. Eflornithine is a myelosuppressivedrug that causes high incidences of anemia, leukopenia,and thrombocytopenia. Complete blood cell counts must bemonitored during the course of therapy.The irreversible inactivation of ornithine decarboxylaseby eflornithine is accompanied by decarboxylation andrelease of fluoride ion from the inhibitor, suggesting enzyme-catalyzed activation of the inhibitor. Only the (—) isomer,stereochemically related to L-ornithine, is active.<br/>Eflornithine is supplied as the hydrochloride salt. It may beadministered either intravenously or orally. Approximately80% of the unchanged drug is excreted in the urine.Penetration of eflornithine into the CSF is facilitated by inflammationof the meninges.
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- Company Name:Hubei Jusheng Technology Co.,Ltd
- Tel:027-59599241 18871490274
- Products Intro:Product Name:Eflornithine
CAS:67037-37-0
Purity:99% HPLC Package:25KG;200KG;5KG;1KG;1T More... - CB Index:58
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- Company Name:Hefei TNJ Chemical Industry Co.,Ltd.
- Tel:+86-0551-65418684 +8618949823763
- Products Intro:Product Name:Eflornithine
CAS:67037-37-0
- CB Index:58
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- Company Name:Dayang Chem (Hangzhou) Co.,Ltd.
- Tel:571-88938639 +8617705817739
- Products Intro:Product Name:Eflornithine
CAS:67037-37-0
Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:Wholesale price - CB Index:58
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- Company Name:Shaanxi Dideu Medichem Co. Ltd
- Tel:+86-029-89586680 +86-18192503167
- Products Intro:Product Name:Eflornithine USP/EP/BP
CAS:67037-37-0
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer - CB Index:58
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- Company Name:CONIER CHEM AND PHARMA LIMITED
- Tel: +8618523575427
- Products Intro:Product Name:eflornithine
CAS:67037-37-0
Purity:99% Package:1kg - CB Index:58
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- Company Name:Sanover (Xiamen) Technology Co., Ltd
- Tel:059265188632; 13876246362
- Products Intro:Product Name:Eflornithine
CAS:67037-37-0
Purity:98%+ Package:25kg - CB Index:58
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