Methyldopa
555-30-6 Basic informationMore
- Product Name:Methyldopa
- Synonyms: Methyldopa (EDMF/COS) L-A-METHYL DOPA MK-351, METHYLDOPA MethyldopaUsp28/Bp2003/Ep5 3-Hydroxy-α-methyl-L-tyrosine L-Tyrosine, 3-hydroxy-.alpha.-methyl- 2-METHYL-3-(3,4-DIHYDROXYPHENYL)ALANINE (2S)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid 3-(3,4-Dihydroxyphenyl)-α-methyl-L-alanine
- CAS:555-30-6
- MF:C10H13NO4
- MW:211.22
- EINECS:209-089-2
- Mol File:555-30-6.mol
-
USE
Methyldopa differs structurally from L-DOPA only in the presence of a -methyl group. Originally synthesized as an AADC inhibitor,methyldopa ultimately decreases the concentration of DA,NE, E, and serotonin in the CNS and periphery. However,its mechanism of action is not caused by its inhibition ofAADC but, rather, by its metabolism in the CNS to its activemetabolite ( β-methylnorepinephrine). Methyldopa istransported actively into CNS via an aromatic amino acidtransporter, where it is decarboxylated by AADC in thebrain to (1R,2S)- α-methyldopamine. This intermediate, inturn, is stereospecifically β-hydroxylated by DBH to givethe (1R,2S)-α-methylnorepinephrine. This active metaboliteis a selective α2-agonist because it has correct(1R,2S) configuration . It is currently postulated that α-methylnorepinephrine acts on α2-receptors in theCNS in the same manner as clonidine, to decrease sympatheticoutflow and lower blood pressure.
Lastest Price from Methyldopa manufacturers
- Methyldopa
-
- US $15.00 /kg
- CAS:555-30-6
- Min. Order: 1kg
- Purity: 99.912%
- Supply Ability: 10ton
- 2024-04-25
- Methyldopa
-
- US $0.00 /kg
- CAS:555-30-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
- 2024-04-07
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- Company Name:Zhejiang Yefeng Pharmaceutical Co., Ltd.
- Tel:86-579-86733319
- Products Intro:Product Name:alpha-methyldopa
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- CB Index:58
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Purity:98% Package:1G;5G More... - CB Index:76
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Purity:98% Package:5g;25g Remarks:D1817 More... - CB Index:62
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:L-(-)-α-Methyldopa;3-(3,4-Dihydroxyphenyl)-α-Methyl-L-alanine
CAS:555-30-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine Sesquihydrate
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Purity:98.0% LC&T Package:25G,5G More... - CB Index:81
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- Company Name:Energy Chemical
- Tel:021-021-58432009 400-005-6266
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