Di-tert-butyl dicarbonate
24424-99-5 Basic informationMore
- Product Name:Di-tert-butyl dicarbonate
- Synonyms: (BOC)2O FLUKA RARECHEM TB OC 0001 (t.-Boc)2O di(tert-butyl) carbonate Di-tert-bicarbonate Di-tert-butyl dicarbonate,Diboc DI-TERT-BUTYL PYROCARBONATE GRADE II DI-TERT-BUTYL DICARBONATE, 1.0M SOLUTION IN TETRAHYDROFURAN
- CAS:24424-99-5
- MF:C10H18O5
- MW:218.25
- EINECS:246-240-1
- Mol File:24424-99-5.mol
USE
Di-tert-butyl dicarbonate (Boc2O) and di-tert-butyl tricarbonate ((BocO)2CO) have been used as amine carbonylating reagents to obtain linear or branched aliphatic isocyanates.<br />
most of the known methods for transforming amines into isocyanates are not mild enough and furnish undefined products as a result of uncontrolled side reactions. However, 4-dimethylaminopyridine (DMAP)-catalyzed reaction with activated carbonates as C1 building blocks constitutes a convenient laboratory method for the phosgene-free isocyanation of amines. A procedure has been described whereby alkyl- and arylamines are converted into isocyanates in high yields by reaction with activated carbonates (for example, di-tert-butyl dicarbonate, Boc2O) in the presence of a catalytic amount of a nucleophilic nitrogen base at room temperature.<br />
Di-tert-butyl dicarbonate (Boc2O) is a widely used reagent for introducing protecting groups in peptide synthesis. The reaction of substituted anilines with Boc2O in the presence of a stoichiometric amount of 4-dimethylaminopyridine (DMAP) in an inert solvent (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) at room temperature leads to aryl isocyanates in almost quantitative yields within 10 min.
Lastest Price from Di-tert-butyl dicarbonate manufacturers
- Di-tert-butyl dicarbonate
- US $0.00 /Kg/Drum
- CAS:24424-99-5
- Min. Order: 1KG
- Purity: 99%min
- Supply Ability: 10 tons
- 2024-11-21
- Di-tert-butyl dicarbonate
- US $3.50 /kg
- CAS:24424-99-5
- Min. Order: 1kg
- Purity: ≥99%
- Supply Ability: 3000tons/month
- 2024-11-21
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- Company Name:NANJING SHUNXIANG PHARMACEUTICAL TECHNOLOGY CO.,LTD.
- Tel:13951004015 13913839793
- Products Intro:Product Name:Di-tert-butyl dicarbonate
CAS:24424-99-5
Purity:70% Package:50KG More... - CB Index:58
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CAS:24424-99-5
Purity:99% Package:50kg - CB Index:58
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CAS:24424-99-5
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CAS:24424-99-5
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CAS:24424-99-5
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CAS:24424-99-5
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- Company Name:Shanghai Yanze Chemical Co., Ltd.
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CAS:24424-99-5
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