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nimotuzumab

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828933-51-3 Basic informationMore
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Overexpression of epidermal growth factor receptor (EGFR), a transmembrane receptor tyrosine kinase, is prevalent in malignant tumors of epithelial origin and is especially common in breast, head and neck, colon, and lung cancer. With EGFR overexpression, prognosis is poor due to associated tumor invasion, metastasis, enhanced angiogenesis, and resistance to chemotherapy; thus, modulation of EGFR-mediated signaling is an attractive target for intervention. Small-molecule kinase inhibitors (gefitinib and erlotinib) and a monoclonal antibody (cetuximab) specific for EGFR are in clinical evaluation, but treatment cessation due to development of severe acne-like rash is common with these EGFR antagonists. Notably, nimotuzumab, a humanized form of the murine IgG2a monoclonal antibody that has been launched in India for treatment of head and neck cancers overexpressing EGFR, demonstrates clinical efficacy devoid of the rash toxicity. .

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  • Company Name:Shanghai EFE Biological Technology Co., Ltd.
  • Tel:021-65675885 18964387627
  • Products Intro:Product Name:Nimotuzumab
    CAS:828933-51-3
    Purity:95% Package:2mg;5mg;10mg More...
  • CB Index:58
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  • Company Name:ShangHai Biochempartner Co.,Ltd
  • Tel:177-54423994 17754423994
  • Products Intro:Product Name:Nimotuzumab
    CAS:828933-51-3
    Purity:95% Package:100ug;500ug;1mg More...
  • CB Index:62
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  • Company Name:Guangzhou Hongyuan Chemical Co.,Ltd
  • Tel: 15817493340
  • Products Intro:Product Name:Nimotuzumab
    CAS:828933-51-3
    Purity:95% Package:1mg;1g;100g
  • CB Index:58
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  • Company Name:Wuhan Chemstan Biotechnology Co., Ltd.
  • Tel:027-65317797 15926423062
  • Products Intro:Product Name:Nimotuzumab
    Purity:>95%;1mg/ml Package:200ug;500ug;1mg
  • CB Index:58
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  • Company Name:Jiangxi ravel Biotechnology Co.,Ltd
  • Tel:400-880-2824; 13184580281
  • Products Intro:Product Name:Nimotuzumab
    CAS:828933-51-3
    Purity:98%+ Package:1毫克 5毫克
  • CB Index:58
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